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Promises under pressure: the modest predictive power of polygenic risk scores

Crossref DOI link: https://doi.org/10.1038/s41431-025-01996-6

Published Online: 2026-01-08

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Horton, Rachel https://orcid.org/0000-0001-6080-6354
Dunlop, Malcolm https://orcid.org/0000-0002-3033-5851
McCartney, Margaret

Sud, Amit

Sullivan, Richard

Tomlinson, Ian https://orcid.org/0000-0003-3037-1470
Turnbull, Clare https://orcid.org/0000-0002-1734-5772
Houlston, Richard https://orcid.org/0000-0002-5268-0242
Lucassen, Anneke https://orcid.org/0000-0003-3324-4338
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Text and Data Mining valid from 2026-01-08

Version of Record valid from 2026-01-08
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Article History

Received: 28 October 2025

Accepted: 12 November 2025

First Online: 8 January 2026

Competing interests

: The authors declare no competing interests.