Ishigami, Daiichiro https://orcid.org/0000-0003-4437-5421
Namba, Shinichi https://orcid.org/0000-0002-7486-3146
Miyawaki, Satoru https://orcid.org/0000-0001-6369-3391
Mitsui, Jun https://orcid.org/0000-0001-7425-4765
Imai, Hideaki
Shimizu, Masahiro
Hongo, Hiroki
Dofuku, Shogo
Torazawa, Seiei
Teranishi, Yu
Ohara, Kenta
Sakai, Yu
Shimada, Daisuke
Ono, Hideaki
Nakatomi, Hirofumi
Morishita, Shinichi https://orcid.org/0000-0002-6201-8885
Tsuji, Shoji
Okada, Yukinori https://orcid.org/0000-0002-0311-8472
Saito, Nobuhito
Funding for this research was provided by:
MEXT | Japan Society for the Promotion of Science (23H03018)
MEXT | Japan Society for the Promotion of Science (21H03041)
Charitable Trust Mihara Cerebrovascular Disorder Research Promotion Funding
MSD Life Science Foundation
Article History
Received: 17 July 2024
Revised: 31 October 2025
Accepted: 22 January 2026
First Online: 12 February 2026
Competing interests
: The authors declare no competing interests.
: This study was approved by the Human Genome, Gene Analysis Research Ethics Committee of the Faculty of Medicine, The University of Tokyo (approval number G10026; approval date, September 12, 2011). The Ethics Committee of Kanto Neurosurgical Hospital also approved this study (approval date, June 23, 2012). Written informed consent was obtained from the patient or parents/legal guardians for participants under 18.