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Authors
Zhao, Xingle https://orcid.org/0000-0002-3992-2139
Xu, Hongen https://orcid.org/0000-0001-7895-0899
Lian, Chengyu
Hu, Shousen
Zhao, Yue
Wang, Jia
Zhai, Rongqun
Yang, Mihuan
Zhang, Yuanjing
Lu, Wei https://orcid.org/0000-0002-6858-196X
Tang, Wenxue
Wang, Liang https://orcid.org/0000-0003-1555-7277
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Funding
Funding for this research was provided by:
China Postdoctoral Science Foundation (2024M752977)
National Natural Science Foundation of China (82371160)
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Article History
Received: 16 February 2025
Revised: 18 June 2025
Accepted: 22 July 2025
First Online: 21 August 2025
Competing interests
: The authors declare no competing interests.
: All methods were performed in accordance with the relevant guidelines and regulations. All animals were bred in accredited barrier facilities with a controlled environment, feed, and water. The mice were housed in a room with a 12-h light/12-h dark cycle, and both water and food were provided ad libitum. All relevant research was approved by the Institutional Animal Care and Use Committee of Zhengzhou University (Ethics ID: ZZU-LAC20230526 (08)). All experiments were conducted in accordance with the 3Rs principles of animal research: Reduction, Replacement, and Refinement. Animals exhibiting severe health impairment were systematically excluded from analysis based on the following objective indicators: weight loss exceeding 20% of baseline body weight. Informed consent for publication was obtained from all participants.
