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Article History

Received: 20 July 2025

Revised: 13 January 2026

Accepted: 4 February 2026

First Online: 26 February 2026

Competing interests

: JA and CK-M are co-founders of the Global Gene Therapy Initiative (GGTI). JA is a Fellow of the Ugandan National Academy of Sciences (FUNAS). Work conducted for this study was performed while JA was employed at the Fred Hutchinson Cancer Center. JA is now Professor and Vice Chair of the Department of Genetic and Cellular Medicine at the University of Massachusetts Chan Medical School. FM-C and RH have assigned an innovation related to this study (Scalable Methodology for Adapting High-Income Cost-Effectiveness Evidence to Low-Resource Healthcare Settings) to the University of Washington. At the time of manuscript submission, this innovation is not protected by a patent. None of the remaining authors declare any conflicts of interest.

: This study did not involve human participants, animals, or the collection of identifiable personal data. All analyses were conducted using publicly available, previously published data sources and simulation models. All methods were performed in accordance with the relevant guidelines and regulations. Because no primary data collection involving human participants or live vertebrates was performed, approval from an ethics committee was not required, and informed consent was not applicable. No identifiable images of human research participants are included in this article; therefore, written informed consent for publication of images was not required.