Yang, Fan https://orcid.org/0000-0001-9697-7016
Dong, Yin
Wu, Siqi
You, Yanting
Yang, Ying
Kong, Jingwei
Chen, Jie
Chen, Liqian
Jiang, Xuefeng
Kwan, Hiu Yee https://orcid.org/0000-0002-6088-7323
Zhao, Xiaoshan
Wang, Ji https://orcid.org/0000-0002-1844-8220
Liu, Yanyan https://orcid.org/0000-0002-9264-1192
Article History
Received: 10 July 2024
Revised: 11 October 2025
Accepted: 17 October 2025
First Online: 6 November 2025
Competing interests
: This work was supported by the National Natural Science Foundation of China (Nos.82474527 and 82074289), the Major scientific and technological project of Guangzhou Municipal Health Commission [No. 20252D003], Postdoctoral Science Foundation of China (2022M711536), Postdoctoral Innovation Program of Shandong Province (SDCX-ZG-202501030), the Natural Science Foundation of Guangdong Province of China (2021A1515010673, 2023A1515011078), Traditional Chinese Medicine Administration Project of Guangdong Province of China (20221438), Medical Scientific Research Foundation of Guangdong Province of China (A2021103), Science and Technology Program of Yangjiang of China (SF2021049, SF2022001) and the Scientific Research Fund of Yangiang People’s Hospital of China (G2021003, G2021004). The authors have declared that no competing interest exists. We would like to express our gratitude to the authors of three datasets: TCGA, GSE25055, and GSE25065.