Chirmade, Shalvi https://orcid.org/0009-0002-2015-6718
Wang, Zhuozhi
Mastromatteo, Scott
Sanders, Eric
Thiruvahindrapuram, Bhooma https://orcid.org/0000-0003-1128-008X
Nalpathamkalam, Thomas
Pellecchia, Giovanna
Lin, Fan
Keenan, Katherine
Patel, Rohan V. https://orcid.org/0000-0001-8674-9706
Sung, Wilson WL
Roshandel, Delnaz
Whitney, Joe
Allana, Sana
Avolio, Julie
Eckford, Paul DW
Ratjen, Felix
Strug, Lisa J. https://orcid.org/0000-0003-0503-9740
Article History
Received: 20 January 2025
Revised: 20 October 2025
Accepted: 21 October 2025
First Online: 7 November 2025
Competing interests
: The authors declare no competing interests.
: SickKids Program in Individualized CF Therapy (CFIT) was approved by the Research Ethics Board of the Hospital for Sick Children (#1000044783 from 2014 to present) and sub-site St. Michael’s Hospital (#14 188 from 2015 to present). Written informed consent was obtained from all participants or parents/guardians/substitute decision makers prior to inclusion in the study.