Zekonyte, Ugne
Bacman, Sandra R.
Smith, Jeff
Shoop, Wendy
Pereira, Claudia V.
Tomberlin, Ginger
Stewart, James https://orcid.org/0000-0002-2902-4968
Jantz, Derek
Moraes, Carlos T.
Article History
Received: 20 November 2020
Accepted: 26 April 2021
First Online: 28 May 2021
Competing interests
: The authors declare the following competing interests: W.S., J.S., G.T., and D.J. work at Precision BioSciences, which is researching and developing ARCUS technology, and may research, develop, and commercialize mitochondria-targeted ARCUS nucleases in the future. C.T.M., D.J., G.T., and W.S. are named in a joint patent application (Patent applicant- Precision BioSciences, Inc. and the University of Miami; application number: 63/178,269; status: pending) for mitochondria-targeted ARCUS nucleases with Precision BioSciences. Specific aspect of manuscript covered in patent application: ARCUS nuclease sequences and compositions for targeting mitochondria, including delivery vectors; Methods of modifying cells, Treating mitochondrial conditions in vivo using the disclosed ARCUS nucleases. All other authors declare no competing interests.