Koehler Leman, Julia https://orcid.org/0000-0002-5693-3593
Lyskov, Sergey https://orcid.org/0000-0001-6380-6712
Lewis, Steven M.
Adolf-Bryfogle, Jared https://orcid.org/0000-0001-8586-1907
Alford, Rebecca F.
Barlow, Kyle https://orcid.org/0000-0002-9787-0066
Ben-Aharon, Ziv https://orcid.org/0000-0002-9623-6071
Farrell, Daniel https://orcid.org/0000-0001-7024-7998
Fell, Jason https://orcid.org/0000-0001-6680-2936
Hansen, William A.
Harmalkar, Ameya https://orcid.org/0000-0001-6863-9634
Jeliazkov, Jeliazko https://orcid.org/0000-0003-4249-1955
Kuenze, Georg
Krys, Justyna D. https://orcid.org/0000-0002-5318-8831
Ljubetič, Ajasja https://orcid.org/0000-0002-2171-1579
Loshbaugh, Amanda L.
Maguire, Jack
Moretti, Rocco
Mulligan, Vikram Khipple
Nance, Morgan L. https://orcid.org/0000-0003-0997-9393
Nguyen, Phuong T.
Ó Conchúir, Shane
Roy Burman, Shourya S. https://orcid.org/0000-0001-9274-9104
Samanta, Rituparna
Smith, Shannon T. https://orcid.org/0000-0002-1225-8928
Teets, Frank
Tiemann, Johanna K. S. https://orcid.org/0000-0001-7551-6245
Watkins, Andrew
Woods, Hope https://orcid.org/0000-0001-6615-545X
Yachnin, Brahm J. https://orcid.org/0000-0001-6812-6329
Bahl, Christopher D.
Bailey-Kellogg, Chris
Baker, David https://orcid.org/0000-0001-7896-6217
Das, Rhiju https://orcid.org/0000-0001-7497-0972
DiMaio, Frank
Khare, Sagar D.
Kortemme, Tanja
Labonte, Jason W.
Lindorff-Larsen, Kresten https://orcid.org/0000-0002-4750-6039
Meiler, Jens https://orcid.org/0000-0001-8945-193X
Schief, William https://orcid.org/0000-0002-1120-0150
Schueler-Furman, Ora https://orcid.org/0000-0002-1624-0362
Siegel, Justin B.
Stein, Amelie https://orcid.org/0000-0002-5862-1681
Yarov-Yarovoy, Vladimir https://orcid.org/0000-0002-2325-4834
Kuhlman, Brian https://orcid.org/0000-0003-4907-9699
Leaver-Fay, Andrew https://orcid.org/0000-0003-4609-4340
Gront, Dominik
Gray, Jeffrey J. https://orcid.org/0000-0001-6380-2324
Bonneau, Richard https://orcid.org/0000-0003-4354-7906
Funding for this research was provided by:
Simons Foundation
Article History
Received: 8 April 2021
Accepted: 2 November 2021
First Online: 29 November 2021
Competing interests
: Rosetta software has been licensed to numerous non-profit and for-profit organizations. Rosetta Licensing is managed by UW CoMotion, and royalty proceeds are managed by the RosettaCommons. Under institutional participation agreements between the University of Washington, acting on behalf of the RosettaCommons, their respective institutions may be entitled to a portion of the revenue received on licensing Rosetta software including programs described here. D.B., J.J.G., R.B., O.S.F., D.G., T.K., J.M., and V.Y.Y. are unpaid board members of the RosettaCommons. As members of the Scientific Advisory Board of Cyrus Biotechnology, D.B. and J.J.G. are granted stock options. S.M.L., A.L.L., and D.F. are employed by or have a relationship with Cyrus Biotechnology. Cyrus Biotechnology distributes the Rosetta software, which includes the methods discussed in this study. V.K.M. is a co-founder of and shareholder in Menten Biotechnology Labs, Inc. The content of this manuscript is relevant to work performed at Menten. J.M. is employed by Menten with granted stock options. D.B. is a cofounder of, shareholder in, or advisor to the following companies: ARZEDA, PvP Biologics, Cyrus Biotechnology, Cue Biopharma, Icosavax, Neoleukin Therapeutics, Lyell Immunotherapeutics, Sana Biotechnology, and A-Alpha Bio. CBK is a co-founder and manager of Stealth Biologics, LLC, a biotechnology company. R.B. is executive director of Prescient Design/Genentech, a member of the Roche group. The remaining authors declare no competing interests.