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Authors
Tessier, Shannon N. https://orcid.org/0000-0003-2373-232X
de Vries, Reinier J.
Pendexter, Casie A. https://orcid.org/0000-0003-0484-6997
Cronin, Stephanie E. J.
Ozer, Sinan
Hafiz, Ehab O. A. https://orcid.org/0000-0002-1551-4309
Raigani, Siavash https://orcid.org/0000-0003-2762-7287
Oliveira-Costa, Joao Paulo
Wilks, Benjamin T.
Lopera Higuita, Manuela
van Gulik, Thomas M.
Usta, Osman Berk
Stott, Shannon L.
Yeh, Heidi
Yarmush, Martin L.
Uygun, Korkut https://orcid.org/0000-0003-2088-7860
Toner, Mehmet https://orcid.org/0000-0002-3647-3665
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Funding
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (K99/R00 HL1431149, R01HL157803)
U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute
American Heart Association (18CDA34110049)
U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (R01DK114506, R01DK114506, R01DK096075, R01DK107875, R01DK114506)
U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases
U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases
U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases
U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases
National Science Foundation (EEC 1941543)
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Article History
Received: 25 May 2020
Accepted: 20 June 2022
First Online: 15 July 2022
Competing interests
: The authors declare competing interests. M.T., K.U., R.J.V., S.N.T., O.B.U., S.L.S., M.L.Y., S.E.J.C., and C.A.P. have patent applications relevant to this study. These include: (1) ML Yarmush, TA Berendsen, R Bieganski, ML Izamis, S Perk, M Toner, OB Usta, B Uygun, MK Uygun (2011) Methods and Compositions for Preserving Tissues and Organs. US Patent Application No. 13/695,459 (Issued); US Patent Divisional Application No. 16/705,966 (pending). This invention relates to methods for high subzero non-freezing storage (i.e. supercooling). (2) SL Stott, SN Tessier, L Weng, M Toner (2016) Ice nucleation formulation for cryopreservation and stabilization of biologics. US Patent Application No. 16/313,714 (pending); Canada Patent Application No. 3,029.669 (pending); European Patent Application No. 17821252.8 (pending); Japan Patent Application No. 2018-568442 (pending). This invention relates to methods to initiate ice nucleation. (3) SEJ Cronin, RJ de Vries, CA Pendexter, SL Stott, SN Tessier, M Toner, MK Uygun, L Weng (2017) High subzero cryopreservation. US Patent Application No. 16/622,457 (pending); European Patent Application No. 18816781.1 (pending). This invention relates to methods for high subzero freezing storage. Further, KU has a financial interest in Organ Solutions, a company focused on developing organ preservation technology. M.T., K.U., and S.N.T. serve on the Scientific Advisory Board for Sylvatica Biotech Inc., a company focused on developing high subzero organ preservation technology. All competing interests are managed by the MGH and Mass General Brigham in accordance with their conflict-of-interest policies. The remaining authors declare no competing interests.
