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Authors
Quintana, Juan F. http://orcid.org/0000-0002-5092-5576
Chandrasegaran, Praveena
Sinton, Matthew C. http://orcid.org/0000-0003-1292-799X
Briggs, Emma M. http://orcid.org/0000-0002-6740-8882
Otto, Thomas D. http://orcid.org/0000-0002-1246-7404
Heslop, Rhiannon http://orcid.org/0000-0002-4332-4393
Bentley-Abbot, Calum http://orcid.org/0000-0002-0087-0028
Loney, Colin http://orcid.org/0000-0002-0508-1781
de Lecea, Luis http://orcid.org/0000-0002-8921-5942
Mabbott, Neil A. http://orcid.org/0000-0001-7395-1796
MacLeod, Annette
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Funding
Funding for this research was provided by:
Wellcome Trust (221640/Z/20/Z, 104111/Z/14/ZR)
RCUK | Biotechnology and Biological Sciences Research Council (BBS/E/D/20231762, BBS/E/D/20002174)
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Article History
Received: 5 April 2022
Accepted: 21 September 2022
First Online: 30 September 2022
Competing interests
: The authors declare no competing interests.
: All animal experiments were approved by the University of Glasgow Ethical Review Committee and performed in accordance with the home office guidelines, UK Animals (Scientific Procedures) Act, 1986 and EU directive 2010/63/EU. All experiments were conducted under SAPO regulations and UK Home Office project licence number PC8C3B25C to Dr. Jean Rodger. The in vivo work related to the single cell and spatial transcriptomic experiments were conducted at 25- and 45-days post-infection (dpi) and correlated with increased clinical scores and procedural severity. Subsequent in vivo experiments for experimental validation (flow cytometry and imaging) were terminated earlier in line with ethical recommendations from the veterinary team at the University of Glasgow.
