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Authors
Li, Lin https://orcid.org/0000-0003-4087-6149
Gupta, Esther
Spaeth, John
Shing, Leslie https://orcid.org/0000-0003-3677-6698
Jaimes, Rafael https://orcid.org/0000-0002-5493-0399
Engelhart, Emily
Lopez, Randolph
Caceres, Rajmonda S.
Bepler, Tristan https://orcid.org/0000-0001-5595-9954
Walsh, Matthew E.
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Article History
Received: 6 December 2022
Accepted: 23 May 2023
First Online: 12 June 2023
Competing interests
: T.B. is the co-founder and CEO of NE47 Bio Inc., a company that provides machine learning services and software for protein engineering. R.L. is a co-founder and current employee of AAlpha Bio, Inc. (A-Alpha Bio) and owns stock/stock options of A-Alpha Bio. E.E. is an employee of A-Alpha Bio and owns stock/stock options of A-Alpha Bio. The remaining authors, L.L., E.G., J.S., L.S., R.J., R.C. and M.W. declare no financial and non-financial competing interests. Massachusetts Institute of Technology has filed a provisional patent application (63/373682) on the end-to-end method for generating scFv libraries; inventors include L.L., E.G., J.S., L.S., R.J., R.C., T.B. and M.W. A-Alpha Bio has a patent (US10988759B2) relating to certain research described in this article.© 2023 Massachusetts Institute of Technology. Subject to FAR52.227-11 Patent Rights - Ownership by the contractor (May 2014). Delivered to the U.S. Government with Unlimited Rights, as defined in DFARS Part 252.227-7013 or 7014 (Feb 2014). Notwithstanding any copyright notice, U.S. Government rights in this work are defined by DFARS 252.227-7013 or DFARS 252.227-7014 as detailed above. Use of this work other than as specifically authorized by the U.S. Government may violate any copyrights that exist in this work.
