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Deleterious heteroplasmic mitochondrial mutations are associated with an increased risk of overall and cancer-specific mortality

Crossref DOI link: https://doi.org/10.1038/s41467-023-41785-7

Published Online: 2023-09-30

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Hong, Yun Soo

Battle, Stephanie L. https://orcid.org/0000-0002-3131-0605
Shi, Wen https://orcid.org/0000-0002-2886-2361
Puiu, Daniela

Pillalamarri, Vamsee

Xie, Jiaqi

Pankratz, Nathan https://orcid.org/0000-0001-5958-693X
Lake, Nicole J.

Lek, Monkol https://orcid.org/0000-0003-1227-6293
Rotter, Jerome I. https://orcid.org/0000-0001-7191-1723
Rich, Stephen S. https://orcid.org/0000-0003-3872-7793
Kooperberg, Charles https://orcid.org/0000-0002-7986-8560
Reiner, Alex P. https://orcid.org/0000-0002-1427-4470
Auer, Paul L. https://orcid.org/0000-0003-1735-8044
Heard-Costa, Nancy https://orcid.org/0000-0001-9730-0306
Liu, Chunyu

Lai, Meng https://orcid.org/0000-0003-3666-838X
Murabito, Joanne M.

Levy, Daniel

Grove, Megan L. https://orcid.org/0000-0001-6764-2508
Alonso, Alvaro https://orcid.org/0000-0002-2225-8323
Gibbs, Richard

Dugan-Perez, Shannon

Gondek, Lukasz P. https://orcid.org/0000-0002-1551-3496
Guallar, Eliseo

Arking, Dan E. https://orcid.org/0000-0001-8980-8695
Funding

Funding for this research was provided by:

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (R01HL144569)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (K24HL148521)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (R01HL156144)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (75N92020D00001)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (3U54HG003273-12S2)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (3R01HL092577- 06S1)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (3R01HL-117626-02S1)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (R01HL-120393)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (U01HL-120393)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (UM1 HG008898)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (R01HL131136)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (3U54HG003067-13S1)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (3R01HL-120393-02S1)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (N01-HC-95159)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (75N92020D00005)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (N01-HC-95160)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (75N92020D00002)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (N01-HC-95161)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (75N92020D00003)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (N01-HC-95162)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (75N92020D00006)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (N01-HC-95163)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (75N92020D00004)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (N01-HC-95164)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (75N92020D00007)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (N01-HC-95165)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (N01-HC-95166)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (N01-HC-95167)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (N01-HC-95168)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (N01-HC-95169)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (UL1-TR-000040)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (UL1-TR-001079)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (UL1-TR-001420)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (UL1TR001881)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (DK063491)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (R01HL105756)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (3U54HG003067-12S2)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Institute on Aging (R01AG059727/R01HL15569)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

Department of Health | National Health and Medical Research Council (1159456)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (U24 HG008956)

U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (UM1 HG008898)

U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute
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Text and Data Mining valid from 2023-09-30

Version of Record valid from 2023-09-30
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Article History

Received: 14 May 2023

Accepted: 14 September 2023

First Online: 30 September 2023

Competing interests

: The authors declare no competing interests.

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