Bishop, Ryan T. http://orcid.org/0000-0002-1332-4798
Miller, Anna K. http://orcid.org/0000-0002-3099-1648
Froid, Matthew
Nerlakanti, Niveditha http://orcid.org/0000-0001-8808-2220
Li, Tao
Frieling, Jeremy S. http://orcid.org/0000-0002-2181-1836
Nasr, Mostafa M.
Nyman, Karl J.
Sudalagunta, Praneeth R. http://orcid.org/0000-0003-1283-9332
Canevarolo, Rafael R. http://orcid.org/0000-0002-8722-8512
Silva, Ariosto Siqueira
Shain, Kenneth H.
Lynch, Conor C. http://orcid.org/0000-0002-4506-6244
Basanta, David http://orcid.org/0000-0002-8527-0776
Article History
Received: 25 September 2022
Accepted: 4 March 2024
First Online: 19 March 2024
Competing interests
: K.H.S. reports honoraria from Bristol Myers Squibb, Janssen, Adaptive Biotechnology, Sanofi, GlaxoSmithKline, Takeda, Amgen, and Sebia as well as research funding to the institution from AbbVie and Karyopharm. All the other authors have no competing interests.
: All animal studies were approved by the University of South Florida IACUC protocol #7356R and #10955R. Patient clinical samples for ex vivo assays and the corresponding clinical data was accessed through the Moffitt Total Cancer Care database. The Moffitt Total Cancer Care research protocol collects samples and biospecimens from cancer patients including multiple myeloma patients. Investigators obtained signed informed consent from all patients who were enrolled in Total Cancer Care® (protocols MCC14745 and MCC18608) at H. Lee Moffitt Cancer Center and Research Institute, as approved by the Institutional Review Board. Patient samples were used in accordance with the Declaration of Helsinki, International Ethical Guidelines for Biomedical Research Involving Human Subjects (CIOMS), Belmont Report, and U.S. Common Rule. The medical records were deidentified and provided to us by an honest broker (Raghunandan Reddy Alugubelli) at the Collaborative Data Services Core at Moffitt Cancer Center. Patient derived myeloma cells (<i>n</i> = 86) were isolated from 68 patients, with a median age of 65.1 years (range, 36.0–82.8 years) with 51.16% of samples being from males and 48.84% from females. Neither sex, gender nor age analyses were taken into account. Only the following clinically relevant individual patient information was reviewed: the treatment administered (therapeutic agents, doses, and schedule) prior to biopsy.