Kitsios, Georgios D. http://orcid.org/0000-0002-1018-948X
Sayed, Khaled
Fitch, Adam
Yang, Haopu
Britton, Noel
Shah, Faraaz
Bain, William http://orcid.org/0000-0001-8506-0552
Evankovich, John W. http://orcid.org/0000-0003-2070-0883
Qin, Shulin
Wang, Xiaohong
Li, Kelvin
Patel, Asha
Zhang, Yingze http://orcid.org/0000-0001-6947-2901
Radder, Josiah
Dela Cruz, Charles
Okin, Daniel A. http://orcid.org/0000-0002-3802-4695
Huang, Ching‐Ying http://orcid.org/0009-0006-9890-4789
Van Tyne, Daria http://orcid.org/0000-0001-7284-0103
Benos, Panayiotis V. http://orcid.org/0000-0003-3172-3132
Methé, Barbara
Lai, Peggy http://orcid.org/0000-0001-9501-8606
Morris, Alison
McVerry, Bryan J. http://orcid.org/0000-0002-1175-4874
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (R03 HL162655, P01 HL114453)
U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute
American Lung Association (COVID-19 Respiratory Virus Research)
U.S. Department of Veterans Affairs (IK2BX004886)
Massachusetts General Hospital Translational and Clinical Research Center
Article History
Received: 18 September 2023
Accepted: 13 May 2024
First Online: 3 June 2024
Competing interests
: Dr. Kitsios has received research funding from Karius, Inc, Genentech, Inc, and Pfizer, Inc, all unrelated to this project. Dr. Morris has received research funding from Pfizer, Inc., unrelated to this project. Dr. McVerry has received consulting fees from Boehringer Ingelheim, BioAegis, and Synairgen Research, Ltd. unrelated to this work. All other authors disclosed no conflict of interest.
: The University of Pittsburgh Institutional Review Board (IRB) approved the protocol for the UPMC-ARF and UPMC-COVID cohorts (STUDY19050099). We obtained written or electronic informed consent by all participants or their surrogates in accordance with the Declaration of Helsinki. For the MGH-COVID cohort, the Study protocol #2020P000804 was approved by the Mass General Brigham IRB. For the healthy controls, the University of Pittsburgh IRB approved the study protocols (STUDY19060243 for respiratory biospecimens and STUDY20060312 for stool biospecimens). All participants or their healthcare proxy provided written informed consent to participate.
: We obtained necessary patient/participant consent and the appropriate institutional forms have been archived. Any patient/participant/sample identifiers included were not known to anyone outside the research group so cannot be used to identify individuals.