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Authors
Jeong, Byung-Kwan https://orcid.org/0000-0002-0038-3959
Choi, Won-Il https://orcid.org/0000-0002-4837-0436
Choi, Wonsuk
Moon, Jieun
Lee, Won Hee
Choi, Chan
Choi, In Young
Lee, Sang-Hyun
Kim, Jung Kuk https://orcid.org/0000-0001-6351-7355
Ju, Young Seok https://orcid.org/0000-0002-5514-4189
Kim, Pilhan https://orcid.org/0000-0001-8388-1840
Moon, Young-Ah
Park, Jun Yong https://orcid.org/0000-0001-6324-2224
Kim, Hail https://orcid.org/0000-0002-6652-1349
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Funding
Funding for this research was provided by:
National Research Foundation of Korea (2020M3A9E403869513)
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Article History
Received: 28 October 2023
Accepted: 16 July 2024
First Online: 2 August 2024
Competing interests
: The authors declare no competing interests.
: All animal experiments complied with the relevant ethical regulations. Experimental protocols for this study were approved by the Institutional Animal Care and Use Committee of Korea Advanced Institute of Science and Technology (KAIST). The criteria for terminating the animal experiment were set as follows: if the size of the hepatic tumor measured externally in the mice exceeded a maximum diameter of 20 mm, or if the weight loss was more than 20%. Only one mouse had a tumor size that exceeded the maximum diameter, measuring 21 mm, which was within the margin of human error. Each week, the surface skin of the mouse liver was visually inspected and palpated to assess tumorigenesis, and the weight was measured to ensure compliance with these criteria. Experiments using human specimens were performed in accordance with the ethical guidelines of the 1975 Declaration of Helsinki and written informed consent was obtained from each participant. There was no compensation provided to research subjects for their participation. The study protocol was approved by the Severance Hospital Institutional Review Board (IRB No. 4-2018-0537, Seoul, Korea).
