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Article History
Received: 9 November 2023
Accepted: 19 August 2024
First Online: 13 September 2024
Competing interests
: The authors declare the following competing interests. Funding. Fieldwork for this study was funded by the Center for Non-Communicable Diseases, Pakistan. DNA sequencing was funded by Regeneron Pharmaceuticals Inc. Employment. J.L.R.F., A.R.S., N.B., D.eS., M.C., J.O., J.R., B.Y., M.K., J.B., G.T., S.G., T.D., N.V., L.A.L., A.Z., N.P., F.S., J.M., G.C., P.X., A.B., S.A.D.G., H.M., I.T., K.K., A.E., D.D.A., S.F., W.L., T.C. and R.G.C. consortium members are or were employees of Regeneron Genetics Center L.L.C. or Regeneron Pharmaceuticals Inc. and contributed to this manuscript as part of their regular duties as salaried employees. E.T. and S.C. are or were student interns of Regeneron Genetics Center LLC or Regeneron Pharmaceuticals Inc. and contributed to this manuscript as part of their internship activites. A.R., M.J., M.Z., M.R.M., M.B.L., P.F., and D.S. and S.K. are or were employees of the Center for Non-Communicable Disease and received salaried compensation for their contribution to this manuscript. Personal Financial Interests. J.L.R.F., A.R.S., N.B., D.eS., M.C., J.O., J.R., B.Y., M.K., J.B., G.T., S.G., T.D., N.V., L.A.L., A.Z., N.P., F.S., J.M., G.C., P.X., A.B., S.A.D.G., H.M., I.T., K.K., A.E., D.D.A., S.F., W.L., T.C., and R.G.C. consortium members are or were employees of Regeneron Genetics Center L.LC. or Regeneron Pharmaceuticals Inc. and received stock and stock options as part of their compensation as employees. J.L.R.F., A.R.S., D.S., A.B., and S.K. are named inventors on patent pending US 20230000897A1 that discloses methods of treating subjects having a cerebrovascular disease by administering Neurogenic Locus Notch Homolog Protein 3 (<i>NOTCH3</i>) agents, and methods of identifying subjects having an increased risk of developing a cerebrovascular disease. The remaining authors have no competing interests.