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: Dr. Apostolova received grant or other financial support from the National Institutes of Health (NIH), Alzheimer’s Association, AVID Pharmaceuticals, Life Molecular Imaging, Roche Diagnostics, and Eli Lilly. In addition, she has received consulting fees from Biogen, Two Labs, IQIVA, Florida Department of Health, Genentech, NIH Biobank, Eli Lilly, GE Healthcare, Eisai, and Roche Diagnostics. She has also received payment or honoraria from American Academy of Neurology, MillerMed, National Alzheimer’s Coordinating Center CME, CME Institute, APhA, Purdue University, Mayo Clinic, MJH Physician Education Resource, and Ohio State University. She received support for travel from the Alzheimer’s Association. She has served on Data Safety and Monitoring or Advisory Boards for IQVIA, UAB Nathan Schock Center, New Mexico Exploratory ADRC, and NIA R01 AG061111. She has a leadership role in multiple committees, including the Medical Science Council of the Alzheimer’s Association Greater Indiana Chapter, the Alzheimer’s Association Science Program Committee, and the FDA PCNS Advisory Committee. Finally, Dr. Apostolova holds stock in Cassava Neurosciences and Golden Seeds. Dr. Foroud receives support from multiple NIH grants (U24 NS095871, U24 AG021886, U24 AG056270, U01 AA026103, U10 AA008401, P30 AG010133, R01 AG019771, U01 AG032984, P30 AR072581, U01 AG057195, UL1 TR002529, U19 AG063911; U19 AG063744, U19 AG068054, R01 AG069453, U54 CA196519, R01 AG061146, R01 AG073267, R01 AG074971, U19 AG071754, R01 AG055444, R01 AG070349, U19 AG024904, R01 AG076634, U19 AG079774, U54 CA280897, U19 NS120384); the Michael J. Fox Foundation (MJFF001948); Cohen Veterans Biosciences; The Parkinson’s Disease Foundation; Children’s Tumor Foundation; Broad Institute; Lumind Foundation; and Gates Venture (0432-06-120975). Dr. Jagust has served as a consultant for Biogen, Eisai, Lilly, and Bioclinica. He has an equity interest in Optoceuticals. Aparna Vasanthakumar and Jeffrey F. Waring are employees of AbbVie and may own AbbVie stock. Dr. Hohman receives support from multiple NIH grants (U24-AG074855, P20-AG068082, R01-AG061518, R01-AG059716, R01-AG074012, RF1-AG059869). He also sits on the advisory board for Vivid Genomics and is a Senior Associate Editor for Alzheimer’s and Dementia: Translational Research and Clinical Intervention. Hyun-Sik Yang received personal fees (honorarium) from Genentech, Inc outside the submitted work. Dr. Vemuri receives funding support from the NIH. Dr. Cruchaga has received research support from: GSK and EISAI. The funders of the study had no role in the collection, analysis, or interpretation of data; in the writing of the report; or in the decision to submit the paper for publication. Dr. Cruchaga is a member of the advisory board of Vivid Genomics and Circular Genomics. Dr. Saykin receives support from multiple NIH grants (P30 AG010133, P30 AG072976, R01 AG019771, R01 AG057739, U19 AG024904, R01 LM013463, R01 AG068193, T32 AG071444, U01 AG068057, U01 AG072177 and U19 AG074879). He has also received support from Avid Radiopharmaceuticals, a subsidiary of Eli Lilly (in kind contribution of PET tracer precursor); Bayer Oncology (Scientific Advisory Board); Eisai (Scientific Advisory Board); Siemens Medical Solutions USA, Inc. (Dementia Advisory Board); NIH NHLBI (MESA Observational Study Monitoring Board); Springer-Nature Publishing (Editorial Office Support as Editor-in-Chief, Brain Imaging and Behavior). Dr. Ertekin-Taner receives support from multiple NIH grants (R01 AG061796, U19 AG074879, U01 AG046139, KL2 TR002379), Alzheimer’s Association Zenith Fellows Award and Florida Department of Health. She serves as an advisor to the Framingham Heart Study (NIH NHLBI 75N92019D00031/75N92019F00125). She also has a provisional patent application unrelated to this work. The remaining authors declare no competing interests.

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