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Authors
Punzi, Simona https://orcid.org/0000-0002-8734-6404
Cittaro, Davide https://orcid.org/0000-0003-0384-3700
Gatti, Guido https://orcid.org/0000-0001-6225-2383
Crupi, Gemma https://orcid.org/0000-0003-4822-7645
Botrugno, Oronza A. https://orcid.org/0000-0002-2568-9815
Cartalemi, Antonino Alex https://orcid.org/0000-0003-1523-4443
Gutfreund, Alon https://orcid.org/0000-0002-3891-2908
Oneto, Caterina https://orcid.org/0009-0006-4553-2221
Giansanti, Valentina https://orcid.org/0000-0003-0617-6245
Battistini, Chiara https://orcid.org/0000-0003-3583-290X
Santacatterina, Giovanni
Patruno, Lucrezia
Villanti, Ilaria
Palumbo, Martina
Laverty, Daniel J.
Giannese, Francesca https://orcid.org/0000-0001-8695-649X
Graudenzi, Alex https://orcid.org/0000-0001-5452-1918
Caravagna, Giulio https://orcid.org/0000-0003-4240-3265
Antoniotti, Marco https://orcid.org/0000-0002-2823-6838
Nagel, Zachary https://orcid.org/0000-0003-2104-2093
Cavallaro, Ugo https://orcid.org/0000-0002-0884-6460
Lanfrancone, Luisa https://orcid.org/0000-0002-4523-3815
Yap, Timothy A. https://orcid.org/0000-0002-2154-3309
Draetta, Giulio https://orcid.org/0000-0001-5225-9610
Balaban, Nathalie
Tonon, Giovanni https://orcid.org/0000-0003-2973-5038
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Funding
Funding for this research was provided by:
Fondazione Italiana per la Ricerca sul Cancro (2279, 28987, 26728-2021, 24913)
Ministry of Health, Italy | Agenzia Italiana del Farmaco, Ministero della Salute (RF-2021-12374586)
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Article History
Received: 11 April 2024
Accepted: 20 November 2024
First Online: 3 February 2025
Competing interests
: G.T., D.C., and F.G. have submitted a patent application, pending, covering TnH and GET-seq20. The remaining authors declare no competing interests.
: Investigations have been conducted in accordance with ethical standards and according to National and International guidelines. In vivo studies were performed after approval from our fully authorized animal facility, notification of the experiments to the Ministry of Health (as required by the Italian Law) (IACUC N°1254), and in accordance to EU directive 2010/63. The maximum tumour volume allowed (1500 mm3) was not exceeded. Human tissue biopsies were collected from patients whose informed consent was obtained in writing according to the policies of the Ethics Committee of the San Raffaele Hospital and the regulations of the Italian Ministry of Health. The studies were conducted in full compliance with the Declaration of Helsinki.
