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Authors
Dvorak, Nolan M. https://orcid.org/0000-0003-1280-9918
Wadsworth, Paul A.
Aquino-Miranda, Guillermo
Wang, Pingyuan
Engelke, Douglas S.
Zhou, Jingheng https://orcid.org/0000-0003-0280-6166
Nguyen, Nghi
Singh, Aditya K. https://orcid.org/0000-0001-7549-8163
Aceto, Giuseppe https://orcid.org/0000-0002-7530-6835
Haghighijoo, Zahra
Smith, Isabella I.
Goode, Nana https://orcid.org/0009-0005-1254-3832
Zhou, Mingxiang
Avchalumov, Yosef
Troendle, Evan P. https://orcid.org/0000-0003-4825-4088
Tapia, Cynthia M.
Chen, Haiying
Powell, Reid T. https://orcid.org/0000-0002-6242-8315
Baumgartner, Timothy J.
Singh, Jully
Koff, Leandra
Di Re, Jessica
Wadsworth, Ann E.
Marosi, Mate
Azar, Marc R.
Elias, Kristina
Lehmann, Paul
Mármol Contreras, Yorkiris M.
Shah, Poonam
Gutierrez, Hector https://orcid.org/0000-0002-7474-4876
Green, Thomas A.
Ulmschneider, Martin B. https://orcid.org/0000-0001-8103-0516
D’Ascenzo, Marcello https://orcid.org/0000-0003-0073-412X
Stephan, Clifford https://orcid.org/0000-0003-0657-6484
Cui, Guohong https://orcid.org/0000-0002-4555-028X
Do Monte, Fabricio H. https://orcid.org/0000-0002-1079-0064
Zhou, Jia https://orcid.org/0000-0002-2811-1090
Laezza, Fernanda https://orcid.org/0000-0003-1141-1852
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Funding
Funding for this research was provided by:
U.S. Department of Health Human Services | NIH | National Institute of Mental Health (R01 MH132226, R01 MH120136, R01 MH131570)
U.S. Department of Health Human Services | NIH | National Institute on Drug Abuse (U18 DA052504)
U.S. Department of Health Human Services | NIH | National Institute of General Medical Sciences (T32 GM008280)
U.S. Department of Health Human Services | NIH | National Institute on Aging (T32 AG051131)
U.S. Department of Health Human Services | NIH | National Institute of Environmental Health Sciences (T32 ES007254)
University of Texas Medical Branch (John D. Stobo, M.D. Distinguished Chair Endowment, Edith Robert Zinn Chair Endowment in Drug Discovery)
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Article History
Received: 30 March 2024
Accepted: 17 December 2024
First Online: 2 January 2025
Competing interests
: The corresponding author, F.L., is the founder and president of IonTx Inc., a start-up company focusing on developing regulators of voltage-gated Na<sup>+</sup> channels. The following patent is related to the present study: LAEZ-F-22A: TMB-0170000. Additional information related to the patent is as follows: Patent Int’l Application No: PCT/US24/32688; Title: Non-Peptide Small Molecule FGF14:Nav1.6 Channel Complex Protein-Protein Interaction Modulators; Tech ID: LAEZ-F-22A; Patent Applicant: The Board of Regents of the University of Texas System; Name of the Inventors: Drs. Jia Zhou, Fernanda Laezza, Pingyuan Wang, Nolan M. Dvorak, Paul A. Wadsworth; Status of the Application: Pending; Specific Aspect of the manuscript covered in the patent application: the synthetic route and chemical structure of 1028 is covered in the patent application. All other authors declare that they have no competing interests.
