Moore, Molly M. https://orcid.org/0000-0002-7833-0769
Wekhande, Siddarth https://orcid.org/0009-0008-7539-8718
Issner, Robbyn
Collins, Alejandro https://orcid.org/0009-0009-1975-8376
Cruz, Anna J. https://orcid.org/0000-0002-4517-179X
Liu, Yanjing V.
Javed, Nauman
Casaní-Galdón, Salvador https://orcid.org/0000-0001-8714-3001
Buenrostro, Jason D. https://orcid.org/0000-0001-9958-3987
Epstein, Charles B. https://orcid.org/0000-0001-8358-8345
Mattei, Eugenio https://orcid.org/0000-0002-8889-658X
Doench, John G. https://orcid.org/0000-0002-3707-9889
Bernstein, Bradley E. https://orcid.org/0000-0002-5726-6278
Shoresh, Noam https://orcid.org/0000-0002-5482-5046
Najm, Fadi J. https://orcid.org/0009-0005-8515-3763
Funding for this research was provided by:
Gene Regulation Observatory (Broad Institute) BroadIgnite (Broad Institute) Broad NextGen
Article History
Received: 2 November 2023
Accepted: 10 January 2025
First Online: 4 February 2025
Competing interests
: J.G.D. consults for Microsoft Research, Abata Therapeutics, Servier, Maze Therapeutics, BioNTech, Sangamo, and Pfizer. J.G.D. consults for and has equity in Tango Therapeutics. J.G.D. serves as a paid scientific advisor to the Laboratory for Genomics Research, funded in part by GlaxoSmithKline. J.G.D. receives funding support from the Functional Genomics Consortium: Abbvie, Bristol Myers Squibb, Janssen, Merck, and Vir Biotechnology. J.G.D.’s interests were reviewed and are managed by the Broad Institute in accordance with its conflict of interest policies. J.D.B. is on the scientific advisory board for Camp4 and seqWell and is a consultant at the Treehouse Family Foundation. B.E.B. declares outside interests in Fulcrum Therapeutics, Arsenal Biosciences, HiFiBio, Cell Signaling Technologies, Design Pharmaceuticals, and Chroma Medicine. A provisional patent has been filed on this work (M.M.M. and F.J.N.). The remaining authors declare no competing interests.