Pottier, Cyril https://orcid.org/0000-0002-3049-9346
Küçükali, Fahri https://orcid.org/0000-0002-3835-9639
Baker, Matt https://orcid.org/0009-0001-2691-5757
Batzler, Anthony
Jenkins, Gregory D. https://orcid.org/0000-0001-6408-6227
van Blitterswijk, Marka
Vicente, Cristina T. https://orcid.org/0000-0002-7882-9543
De Coster, Wouter https://orcid.org/0000-0002-5248-8197
Wynants, Sarah
Van de Walle, Pieter
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Murray, Melissa E. https://orcid.org/0000-0001-7379-2545
Faura, Júlia
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Mol, Merel O. https://orcid.org/0000-0003-2533-2530
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Graff, Caroline
Öijerstedt, Linn
Neumann, Manuela
Asmann, Yan
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Baheti, Saurabh https://orcid.org/0000-0002-3564-7627
Josephs, Keith A. https://orcid.org/0000-0003-2930-8634
Whitwell, Jennifer L.
Bieniek, Kevin F. https://orcid.org/0000-0003-4922-864X
Forsberg, Leah https://orcid.org/0000-0003-4086-9598
Heuer, Hilary
Lago, Argentina Lario
Geier, Ethan G.
Yokoyama, Jennifer S. https://orcid.org/0000-0001-7274-2634
Oddi, Alexis P.
Flanagan, Margaret
Mao, Qinwen
Hodges, John R.
Kwok, John B.
Domoto-Reilly, Kimiko https://orcid.org/0000-0002-7396-1633
Synofzik, Matthis https://orcid.org/0000-0002-2280-7273
Wilke, Carlo
Onyike, Chiadi
Dickerson, Bradford C. https://orcid.org/0000-0002-5958-3445
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Dugger, Brittany N. https://orcid.org/0000-0003-2141-8855
Munoz, David G.
Keith, Julia
Zinman, Lorne
Rogaeva, Ekaterina https://orcid.org/0000-0002-2852-0329
Suh, EunRan
Gefen, Tamar
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Diehl-Schmid, Janine
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Reiman, Eric M. https://orcid.org/0000-0002-0705-3696
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Petersen, Ronald C. https://orcid.org/0000-0002-8178-6601
Petrucelli, Leonard
Uitti, Ryan J.
Wszolek, Zbigniew K. https://orcid.org/0000-0001-5487-1053
Ramos, Eliana Marisa
Grinberg, Lea T. https://orcid.org/0000-0002-6809-0618
Tempini, Maria Luisa Gorno
Rosen, Howard J.
Spina, Salvatore https://orcid.org/0000-0003-3570-9143
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Grossman, Murray
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Keene, C. Dirk https://orcid.org/0000-0002-5291-1469
Jin, Lee-Way
Prudlo, Johannes
Geschwind, Daniel H. https://orcid.org/0000-0003-2896-3450
Rissman, Robert A.
Cruchaga, Carlos https://orcid.org/0000-0002-0276-2899
Ghetti, Bernardino https://orcid.org/0000-0002-1842-8019
Halliday, Glenda M. https://orcid.org/0000-0003-0422-8398
Beach, Thomas G.
Serrano, Geidy E.
Arzberger, Thomas
Herms, Jochen https://orcid.org/0000-0002-6201-1042
Boxer, Adam L. https://orcid.org/0000-0002-1215-5064
Honig, Lawrence S. https://orcid.org/0000-0002-9703-2265
Vonsattel, Jean P.
Lopez, Oscar L. https://orcid.org/0000-0002-8546-8256
Kofler, Julia
White, Charles L. III https://orcid.org/0000-0002-3870-2804
Gearing, Marla
Glass, Jonathan https://orcid.org/0000-0002-3295-4971
Rohrer, Jonathan D.
Irwin, David J. https://orcid.org/0000-0002-5599-5098
Lee, Edward B. https://orcid.org/0000-0002-4589-1180
Van Deerlin, Vivianna https://orcid.org/0000-0002-7400-9097
Castellani, Rudolph
Mesulam, Marsel M.
Tartaglia, Maria C. https://orcid.org/0000-0002-5944-8497
Finger, Elizabeth C.
Troakes, Claire https://orcid.org/0000-0002-1790-7376
Al-Sarraj, Safa
Dalgard, Clifton L. https://orcid.org/0000-0003-2025-8239
Miller, Bruce L.
Seelaar, Harro https://orcid.org/0000-0003-1989-7527
Graff-Radford, Neill R.
Boeve, Bradley F. https://orcid.org/0000-0002-4153-8187
Mackenzie, Ian RA. https://orcid.org/0000-0003-3875-2972
van Swieten, John C.
Seeley, William W. https://orcid.org/0000-0003-1410-2027
Sleegers, Kristel https://orcid.org/0000-0002-0283-2332
Dickson, Dennis W. https://orcid.org/0000-0001-7189-7917
Biernacka, Joanna M. https://orcid.org/0000-0001-9350-4440
Rademakers, Rosa https://orcid.org/0000-0002-4049-0863
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (UG3/UH3 NS103870)
Article History
Received: 5 June 2024
Accepted: 15 April 2025
First Online: 25 April 2025
Competing interests
: S.J.H. serves on the scientific advisory board (SAB) of Proximity Therapeutics, Psy Therapeutics, Frequency Therapeutics, Souvien Therapeutics, Sensorium Therapeutics, 4 M Therapeutics, Ilios Therapeutics, Entheos Labs, Alzheimer’s Drug Discovery Foundation, and the Kissick Family Foundation FTD Grant Program, none of whom were involved in the present study. S.J.H. has also received speaking or consulting fees from Amgen, AstraZeneca, Biogen, Merck, Regenacy Pharmaceuticals, Syros Pharmaceuticals, Juvenescence Life, as well as sponsored research or gift funding from AstraZeneca, JW Pharmaceuticals, Lexicon Pharmaceuticals, Vesigen Therapeutics, Compass Pathways, Atai Life Sciences, and Stealth Biotherapeutics. The funders had no role in the design or content of this article. ZKW serves as PI or Co-PI on Biohaven Pharmaceuticals, Inc. (BHV4157-206), Vigil Neuroscience, Inc. (VGL101-01.002, VGL101-01.201, PET tracer development protocol, Csf1r biomarker and repository project, and ultra-high field MRI in the diagnosis and management of CSF1R-related adult-onset leukoencephalopathy with axonal spheroids and pigmented glia), and ONO-2808-03 projects/grants. He serves as Co-PI of the Mayo Clinic APDA Center for Advanced Research and as an external advisory board member for the Vigil Neuroscience, Inc., and as a consultant for Eli Lilly & Company and for NovoGlia, Inc. R.R. and I.R.M. receive royalties from progranulin-related patent. The remaining authors declare no competing interests.