Whiting, Frederick J. H. https://orcid.org/0000-0003-4090-7136
Mossner, Maximilian https://orcid.org/0000-0001-9751-3803
Gabbutt, Calum https://orcid.org/0000-0003-1946-4780
Kimberley, Christopher
Barnes, Chris P. https://orcid.org/0000-0002-9459-1395
Baker, Ann-Marie https://orcid.org/0000-0001-8905-9137
Yara-Romero, Erika
Sottoriva, Andrea https://orcid.org/0000-0001-6709-9533
Nichols, Richard A. https://orcid.org/0000-0002-4801-9312
Graham, Trevor A. https://orcid.org/0000-0001-9582-1597
Funding for this research was provided by:
Cancer Research UK (A19771, DRCNPG-May21_100001)
Wellcome Trust (202778/Z/16/Z)
Article History
Received: 6 March 2024
Accepted: 24 April 2025
First Online: 20 June 2025
Competing interests
: F.J.H.W. and T.A.G. are named as coinventors on a patent application that describes a computational approach to measure the evolutionary dynamics of drug resistance evolution using combined cell population sizes and lineage distributions that arose from this study (GB2501439.0 – Drug Resistance Assays). T.A.G. and A-M.B. are named as a coinventors on a patent application that describes a method for TCR sequencing (GB2305655.9). T.A.G and C.G. are named as coinventors on a patent application that describes a method to measure evolutionary dynamics in cancers using DNA methylation (GB2317139.0). T.A.G. has received honorarium from Genentech and consultancy fees from DAiNA therapeutics. The remaining authors declare no competing interests.