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The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer’s disease

Crossref DOI link: https://doi.org/10.1038/s41467-025-60099-4

Published Online: 2025-05-27

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Murphy, Kitty B.

Hu, Di

Wolfs, Leen

Rohde, Susan K. https://orcid.org/0000-0002-9985-9645
Fauró, Gonzalo Leguía

Geric, Ivana

Mancuso, Renzo

De Strooper, Bart https://orcid.org/0000-0001-5455-5819
Marzi, Sarah J. https://orcid.org/0000-0002-3924-2053
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Text and Data Mining valid from 2025-05-27

Version of Record valid from 2025-05-27
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Article History

Received: 19 July 2024

Accepted: 12 May 2025

First Online: 27 May 2025

Competing interests

: B.D.S. is or has been a consultant for Eli Lilly, Biogen, Janssen Pharmaceutica, Eisai, AbbVie and other companies. B.D.S. is also a scientific founder of Augustine Therapeutics and a scientific founder and stockholder of Muna Therapeutics. The remaining authors declare no competing interests.

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