Noda, Taichi https://orcid.org/0000-0003-0260-7861
Uriu, Reika https://orcid.org/0009-0000-9903-2595
Mashiko, Daisuke https://orcid.org/0000-0003-3927-3076
Shinohara, Hina
Qu, Yongcun
Taira, Ayumu
Matzuk, Ryan M. https://orcid.org/0000-0001-6426-752X
Tahala, Duri https://orcid.org/0009-0008-0211-8631
Nakano, Motochika
Araki, Kimi https://orcid.org/0000-0002-1396-1527
Yu, Zhifeng https://orcid.org/0000-0002-3130-6438
Zhang, Ying https://orcid.org/0000-0003-4082-5026
Matzuk, Martin M. https://orcid.org/0000-0002-1445-8632
Ikawa, Masahito https://orcid.org/0000-0001-9859-6217
Funding for this research was provided by:
MEXT | Japan Society for the Promotion of Science (JP20H03172)
MEXT | Japan Society for the Promotion of Science (JP25K02196)
MEXT | Japan Society for the Promotion of Science (JP25KJ1979)
MEXT | Japan Society for the Promotion of Science (JP22H04922 (AdAMS))
MEXT | Japan Society for the Promotion of Science (JP21H05033)
MEXT | Japan Society for the Promotion of Science (JP23K20043)
MEXT | Japan Society for the Promotion of Science (JP22H04922 (AdAMS))
Takeda Science Foundation
Senri Life Science Foundation
Inamori Foundation
Mochida Memorial Foundation for Medical and Pharmaceutical Research
MEXT | JST | Precursory Research for Embryonic Science and Technology (JPMJPR2148)
The Nakajima Foundation
U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD088412)
U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD088412)
MEXT | JST | Core Research for Evolutional Science and Technology (JPMJCR21N1)
Japan Agency for Medical Research and Development (JP23jf0126001)
OU Master Plan Implementation Project promoted under Osaka University
Article History
Received: 5 March 2025
Accepted: 28 August 2025
First Online: 17 September 2025
Competing interests
: The authors declare no competing interests.