Helzer, Kyle T.
Sharifi, Marina N. https://orcid.org/0000-0003-0128-3033
Sperger, Jamie M.
Chrostek, Matthew R.
Bootsma, Matthew L.
Reese, Shannon R.
Taylor, Amy
Kaufmann, Katie R.
Krause, Hannah https://orcid.org/0000-0002-3154-9990
Schehr, Jennifer
Sethakorn, Nan
Kosoff, David
Kyriakopoulos, Christos E. https://orcid.org/0000-0002-6452-7405
Bassetti, Michael
Blitzer, Grace
Floberg, John
Sjöström, Martin https://orcid.org/0000-0002-2629-9966
Armstrong, Andrew J. https://orcid.org/0000-0001-7012-1754
Beltran, Himisha https://orcid.org/0000-0003-3259-2226
McKay, Rana R. https://orcid.org/0000-0002-0581-7963
Feng, Felix Y. https://orcid.org/0000-0002-0963-7687
O’Regan, Ruth
Wisinski, Kari B.
Emamekhoo, Hamid
Wyatt, Alex W. https://orcid.org/0000-0003-2399-0329
Lang, Joshua M. https://orcid.org/0000-0002-0943-8872
Zhao, Shuang G. https://orcid.org/0000-0002-9166-6507
Funding for this research was provided by:
U.S. Department of Health & Human Services | National Institutes of Health (DP2 OD030734, P50 CA269011, P30 CA014520)
U.S. Department of Defense (PC190039, PC200334, PC240611)
Article History
Received: 17 December 2024
Accepted: 9 September 2025
First Online: 14 October 2025
Competing interests
: The Wisconsin Alumni Research Foundation have filed a patent application (cfDNA fragmentomic detection of cancer; US20240145038A1) on which KTH and SGZ are inventors relevant to this work. KTH has a family member who is an employee of Epic Systems. SGZ has patent applications unrelated to this work with Veracyte, and a spouse who is an employee of Artera with stock, and stock in Exact Sciences. MNS reports institutional research support from Novartis unrelated to this work. MS reports speakers fees from Astellas and advisory board activity for Veracyte/Adelphi Targis. The remaining authors declare no competing interests.