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Authors
Giddins, Marla https://orcid.org/0000-0002-4416-4395
Kratz, Alexander F.
De Los Santos, Mark B. https://orcid.org/0000-0002-7195-5141
Forget, Antoine
Tiwari, Richa https://orcid.org/0000-0003-3069-8510
Jang, Gwendolyn https://orcid.org/0000-0001-7806-9874
Blazejewski, Tomasz
Qin, Chuyan
Huang, Yiming https://orcid.org/0000-0003-1932-2803
Lao, Yeh-Hsing https://orcid.org/0000-0002-7990-199X
Falconer, Thomas https://orcid.org/0000-0001-6904-1394
Leong, Kam. W.
Krogan, Nevan https://orcid.org/0000-0003-4902-337X
Staller, Max https://orcid.org/0000-0001-9094-5697
Wang, Harris
Wei, Lai https://orcid.org/0000-0002-2892-2977
Chavez, Alejandro https://orcid.org/0000-0001-5626-7140
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Funding
Funding for this research was provided by:
United States Department of Defense | Defense Advanced Research Projects Agency (HR0011-19-2-0009)
United States Department of Defense | Defense Advanced Research Projects Agency (HR0011-19-2-0009)
United States Department of Defense | Defense Advanced Research Projects Agency (HR0011-19-2-0009)
U.S. Department of Health & Human Services | National Institutes of Health (DP2NS131566-01)
U.S. Department of Health & Human Services | National Institutes of Health (1R01EB031935)
U.S. Department of Health & Human Services | National Institutes of Health (U54 CA274502)
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Article History
Received: 5 April 2024
Accepted: 24 October 2025
First Online: 20 November 2025
Competing interests
: Columbia University has filed a provisional patent application with the United States Patent and Trademark Office pertaining to the CRISPR activators MHV and MMH described in this work (U.S. Provisional Application No. 63/892,477). The remaining authors declare no competing interests.
