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Article History
Received: 23 July 2025
Accepted: 27 October 2025
First Online: 9 December 2025
Competing interests
: R.S. is a co-founder of mzio GmbH. D.M.: D.M. is a consultant for BiomeSense, Inc., has equity, and receives income. The terms of these arrangements have been reviewed and approved by the University of California, San Diego in accordance with its conflict of interest policies. R.K.-D.: R.K.-D. is an inventor on a series of patents on use of metabolomics for the diagnosis and treatment of CNS diseases and holds equity in Metabolon Inc., Chymia LLC, and PsyProtix. M.W. is a co-founder of Ometa Labs LLC. T.P. is a co-founder of mzio GmbH. R.K. is a scientific advisory board member, and consultant for BiomeSense, Inc., has equity, and receives income. He is a scientific advisory board member and has equity in GenCirq. He has equity in and acts as a consultant for Cybele. He is a co-founder of Biota, Inc., and has equity. He is a cofounder of Micronoma and has equity and is a scientific advisory board member. He is a board member of Microbiota Vault, Inc. He is a board member of N = 1 IBS advisory board and receives income. He is a Senior Visiting Fellow of HKUST Jockey Club Institute for Advanced Study. The terms of these arrangements have been reviewed and approved by the University of California, San Diego, in accordance with its conflict of interest policies. S.M.T.: S.M.T. receives research funding from Veloxis Pharmaceuticals. P.C.D.: P.C.D. is a scientific advisor and holds equity in Cybele, and bileOmix, and is a Scientific Co-founder, advisor, holds equity and/or received income from Ometa, Arome, and Enveda, with prior approval by UC-San Diego. The remaining authors declare no competing interests.