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Intrinsic resistance to RAS inhibitors is driven by dysregulation of KRAS degradation

Crossref DOI link: https://doi.org/10.1038/s41467-025-67109-5

Published Online: 2025-12-15

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Ivanisevic, Tonci

Ma, Yan

Van Boxel, Emiel https://orcid.org/0000-0003-0879-4530
Magits, Wout https://orcid.org/0000-0002-4068-8300
Lechat, Benoit

Koçberber, Zeynep

Willnow, Phillipp https://orcid.org/0000-0001-7910-7748
Fendt, Sarah-Maria https://orcid.org/0000-0001-6018-9296
Velde, Greetje Vande https://orcid.org/0000-0002-5633-3993
Sewduth, Raj https://orcid.org/0000-0002-9238-3242
Sablina, Anna A https://orcid.org/0000-0001-9526-4014
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Text and Data Mining valid from 2025-12-15

Version of Record valid from 2026-01-12
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Article History

Received: 12 November 2024

Accepted: 13 November 2025

First Online: 15 December 2025

Competing interests

: The authors declare no competing interests.