Okuwa, Takako https://orcid.org/0009-0004-3981-4674
Himeda, Toshiki https://orcid.org/0009-0005-2970-1972
Kobayashi, Kyousuke https://orcid.org/0000-0001-5501-8396
Nomura, Namiko
Utani, Kouichi
Koike, Satoshi https://orcid.org/0000-0002-2745-5254
Nakamura, Akira
Higuchi, Masaya https://orcid.org/0000-0002-7584-5281
Funding for this research was provided by:
MEXT | Japan Society for the Promotion of Science (25K10386)
MEXT | Japan Society for the Promotion of Science (21K07045)
MEXT | Japan Society for the Promotion of Science (24K10234)
Japan Agency for Medical Research and Development (JP25fk0108716)
Kanazawa Medical University (S2023-4)
Kanazawa Medical University (K2024-3)
Yakult Honsha Co., Ltd.
Article History
Received: 3 December 2024
Accepted: 25 November 2025
First Online: 15 December 2025
Competing interests
: The authors declare no competing interests.