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Authors
Horii, Takuro https://orcid.org/0009-0004-2167-1791
Morita, Sumiyo
Hino, Shinjiro
Hino, Yuko
Fukushima, Hiroto S. https://orcid.org/0009-0003-0736-3680
Kobayashi, Ryosuke https://orcid.org/0009-0009-8666-1312
Kimura, Mika
Nakao, Mitsuyoshi
Mizukami, Yoichi https://orcid.org/0000-0002-3290-0754
Inoue, Azusa https://orcid.org/0000-0002-9703-0358
Hatada, Izuho https://orcid.org/0000-0001-7225-3929
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Funding
Funding for this research was provided by:
MEXT | Japan Society for the Promotion of Science (23K23802, Scientific Research (B))
MEXT | Japan Society for the Promotion of Science (23K05727, Scientific Research (C))
MEXT | Japan Society for the Promotion of Science (24KJ0236)
MEXT | Japan Society for the Promotion of Science (25H01355)
MEXT | Japan Society for the Promotion of Science (24K02582, Scientific Research (B))
the Joint Usage/Research Center for Developmental Medicine, IMEG, Kumamoto University
Japan Agency for Medical Research and Development (22gm6310009h0004)
Japan Agency for Medical Research and Development (JP21am0101120 and JP24ama121049)
Japan Agency for Medical Research and Development (21ek0109489h0002)
MEXT | Japan Science and Technology Agency (JPMJFR2335)
the Tokyo Biochemical Research Foundation, the Takeda Science Foundation, the Uehara Memorial Foundation, and the Life Science Institute, Inc.
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Article History
Received: 19 December 2024
Accepted: 2 December 2025
First Online: 25 December 2025
Competing interests
: The authors declare that a patent application related to this work has been filed by Gunma University (Japanese Patent Application No. 2023-522326; currently under examination). The inventors are I.H., T.H., and S.M. The patent pertains to methods for germline epigenome editing. This research was funded by the LSII, Inc. The funder provided financial support to I.H. and was involved in the data analysis presented in Supplementary Fig. ; however, the decision to publish and the preparation of the manuscript were made independently by the authors. S.H., Y.H., H.F., R.K., M.K., M.N., Y.M., and A.I. declare no competing interests.
