Li, Yu
Gong, Fei
Wang, Xiaohong
Hu, Linli
Li, Hong
Guan, Yichun https://orcid.org/0000-0002-6255-2551
Ye, Hong
Fan, Li
Bai, Haiyan
Wang, Ze
Huang, Wei
Ma, Xiaoling
Yang, Dongzi https://orcid.org/0000-0001-9587-1535
Zhang, Heping https://orcid.org/0000-0002-0688-4076
Article History
Received: 1 April 2025
Accepted: 5 December 2025
First Online: 24 December 2025
Competing interests
: The Authors declare the following competing interests. D.Y. reported that she received grants from Guangzhou Baiyunshan Zhongyi Pharmaceutical Co., Ltd. and The Secondary Development Project of Famous and High-quality Chinese Patent Medicine in Guangdong Province (Project No.: 20174002) during the conduct of the study. Y.L. reported that she received grants from the Science and Technology Program of Guangzhou (Project No.: 201704020046) during the conduct of the study. The remaining authors report no competing interests. Guangzhou Baiyunshan Zhongyi Pharmaceutical Co., Ltd. donated the study drugs, including Zishen Yutai Pill and the placebo, for this research. An independent third-party contract research organization (CRO), Guangzhou Evidence-Based Medicine Tech Co., Ltd., was hired by Guangzhou Baiyunshan Zhongyi Pharmaceutical Co., Ltd. for data management. Guangzhou Baiyunshan Zhongyi Pharmaceutical Co., Ltd had no role in the data acquisition, statistical analysis and writing of this article.