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Unbiased clustering of acute-on-chronic liver failure patients using machine learning in a real-world ICU cohort

Crossref DOI link: https://doi.org/10.1038/s41467-026-68368-6

Published Online: 2026-01-20

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Zhang, Mengyi https://orcid.org/0009-0000-2835-0107
Ji, Fanpu https://orcid.org/0000-0002-1463-8035
Zu, Jian https://orcid.org/0000-0003-3633-0725
He, Yingli

Chen, Tao

Liu, Yi https://orcid.org/0000-0001-8433-745X
Trivedi, Hirsh D.

Yang, Ju Dong https://orcid.org/0000-0001-7834-9825
Sundaram, Vinay

Wang, Yuan

Sun, Xiaodan

Cao, Zhujun https://orcid.org/0000-0002-8684-2107
Wu, Chun-Ying https://orcid.org/0000-0001-5053-1801
Yeo, Yee Hui https://orcid.org/0000-0002-2703-5954
Jalan, Rajiv https://orcid.org/0000-0002-7747-4015
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (82170626)

National Natural Science Foundation of China (82473291)

National Natural Science Foundation of China (12471470)

National Natural Science Foundation of China (12071366)
License Information

Text and Data Mining valid from 2026-01-20

Version of Record valid from 2026-02-16
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Article History

Received: 6 July 2025

Accepted: 1 January 2026

First Online: 20 January 2026

Competing interests

: R.J. is the founder of Yaqrit Discovery, Hepyx (spin-out companies from University College London), and Cyberliver. He has research collaborations with Yaqrit Discovery. He reviews grants for Grifols and consults with Boehringer Ingelheim and Cellbricks. F.J.: Speaker: Gilead Sciences, MSD and Ascletis. Consulting/advisory board: Gilead, MSD. J.D.Y. provides a consulting service for AstraZeneca, Eisai, Exact Sciences, and FujiFilm Medical Sciences. All other authors do not have any conflicts of interest.

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