Paduthol, Gauri https://orcid.org/0000-0002-6654-3281
Nikolaev, Mikhail https://orcid.org/0000-0001-5955-900X
Sharma, Kunal https://orcid.org/0000-0001-8086-3436
Blanc, Jérôme
Tomasek, Kathrin https://orcid.org/0000-0003-3768-877X
Schlunke, Léa Ivana Esméralda https://orcid.org/0009-0007-1394-0842
Borgeat, Valentin https://orcid.org/0000-0003-2933-2458
Ambrosini, Giovanna https://orcid.org/0000-0003-1294-6541
Kolotuev, Irina
Clerc-Rosset, Stéphanie
Gjorevski, Nikolche https://orcid.org/0000-0001-8320-0443
Knott, Graham W. https://orcid.org/0000-0002-2956-9052
Lütolf, Matthias P.
Thacker, Vivek V. https://orcid.org/0000-0002-1681-627X
McKinney, John D. https://orcid.org/0000-0002-0557-3479
Funding for this research was provided by:
Novartis Stiftung für Medizinisch-Biologische Forschung (20C240)
University of Heidelberg | Medizinischen Fakultät Heidelberg, Universität Heidelberg
Holcim Stiftung zur Foerderung der Wissenschaflichen, Life Sciences Bridge Award from the Aventis Foundation
Bundesbehörden der Schweizerischen Eidgenossenschaft (2022.0289)
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (TMPFP3_217144)
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (51NF40_180541)
École Polytechnique Fédérale de Lausanne
Fondation Leenaards
Article History
Received: 14 February 2025
Accepted: 5 January 2026
First Online: 3 February 2026
Competing interests
: M.N., N.G., and M.L. are current employees of Hoffmann-La Roche Ltd or were employed by the company while working on this study. The company provided support in the form of salaries for authors but did not have any additional role in the study design, data collection and analysis, decision to publish or preparation of the manuscript. The remaining authors declare no competing interests.