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Inhibition of the cancer stem cell immune checkpoint SOAT1 suppresses regulatory T cell functions through a trans-cellular 20(S)-Hydroxycholesterol-GPR132 pathway in mice

Crossref DOI link: https://doi.org/10.1038/s41467-026-69305-3

Published Online: 2026-03-17

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Ding, Yahui

Fang, Wanqi

Xiang, Ruiqing

Liu, Haitao

Huang, Menglin https://orcid.org/0009-0009-0245-4296
Shen, Yingran

Chen, Ying

Wang, Guohao

Zhou, Zhaocai https://orcid.org/0000-0002-5441-3922
Ling, Yun

Sun, Ling V. https://orcid.org/0000-0003-2410-793X
Wang, Yuetong https://orcid.org/0000-0003-3970-581X
Hou, Steven X. https://orcid.org/0000-0001-7583-2504
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Text and Data Mining valid from 2026-03-17

Accepted Manuscript valid from 2026-03-17
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Article History

Received: 11 May 2025

Accepted: 26 January 2026

First Online: 17 March 2026

Competing interests

: The authors declare no competing interests or personal relationships that could have appeared to influence the work reported in this paper.

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