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Lactate derived from macrophages drives skin dermal fibroblasts phenotypic remodeling via MCT1-primed histone H3 lysine 23 lactylation in hypertrophic scar

Crossref DOI link: https://doi.org/10.1038/s41467-026-69388-y

Published Online: 2026-02-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Yuan, Yixuan https://orcid.org/0009-0007-7432-3813
Xiao, Yujie https://orcid.org/0009-0001-1241-8776
Zou, Jie

Luo, Liang

Li, Mengyang https://orcid.org/0009-0009-8701-6219
Shen, Kuo

Wei, Lai

Zhang, Yihao

Wang, Peng

Chen, Yan https://orcid.org/0000-0002-6630-0693
Zhuo, Shixuan

Zhang, Hao

Song, Shijie

Jia, Yanhui

Wang, Kejia

Jiang, Shiqing

Guan, Hao https://orcid.org/0000-0002-5132-4078
Hu, Dahai https://orcid.org/0000-0002-3640-6729
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Text and Data Mining valid from 2026-02-12

Version of Record valid from 2026-03-23
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Article History

Received: 22 May 2025

Accepted: 30 January 2026

First Online: 12 February 2026

Competing interests

: The authors have declared that no conflict of interest exists.

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