Hirunagi, Tomoki https://orcid.org/0000-0002-1948-0126
Sahashi, Kentaro https://orcid.org/0000-0003-3256-9659
Iida, Madoka https://orcid.org/0000-0002-3394-9760
Onodera, Kazunari
Yokoi, Satoshi
Ogura, Yosuke https://orcid.org/0000-0002-5251-9176
Tohnai, Genki https://orcid.org/0009-0007-3888-1201
Sakakibara, Kenji
Maeda, Kentaro
Bennett, C. Frank
Okada, Yohei https://orcid.org/0000-0001-5253-8556
Katsuno, Masahisa https://orcid.org/0000-0001-9453-9311
Funding for this research was provided by:
MEXT | Japan Society for the Promotion of Science (JP20H00527)
MEXT | Japan Society for the Promotion of Science (JP23H00420)
MEXT | Japan Society for the Promotion of Science (JP24K18683)
MEXT | Japan Society for the Promotion of Science (JP24K18712)
MEXT | Japan Society for the Promotion of Science (JP23K24249)
MEXT | Japan Society for the Promotion of Science (JP25K02585)
Japan Agency for Medical Research and Development (JP22nk0101575)
Japan Agency for Medical Research and Development (JP22am0401007)
Japan Agency for Medical Research and Development (JP22bm0804020)
Japan Agency for Medical Research and Development (P25bm1423003)
Article History
Received: 4 June 2024
Accepted: 23 February 2026
First Online: 27 March 2026
Competing interests
: C.F.B. is an employee of Ionis Pharmaceuticals and owns stock options. Y.Okada is a scientific advisor of Kohjin Bio Co., Ltd. The remaining authors declare no competing interests.