Yang, Xi https://orcid.org/0000-0003-2741-2294
Doray, Balraj https://orcid.org/0000-0003-3347-5013
Henn, Danielle
Venkatarangan, Varsha
Jennings, Benjamin C. https://orcid.org/0000-0002-7255-2715
Dong, Zhongzheng https://orcid.org/0009-0008-7813-7142
Liang, Jiaxuan
Zhang, Weichao https://orcid.org/0000-0002-0835-890X
Zhang, Bokai https://orcid.org/0000-0003-1854-0227
Yu, Linchen
Chen, Liang https://orcid.org/0000-0002-7186-7109
Kornfeld, Stuart https://orcid.org/0000-0002-6417-4478
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD109346)
U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (R01CA008759)
Article History
Received: 27 February 2024
Accepted: 19 February 2026
First Online: 11 March 2026
Competing interests
: S.K. was co-founder of M6P Therapeutics and held stock options in the company. The rest of the authors declare no competing interests.
: We wish to dedicate this paper to the memory of Stuart Kornfeld (1936-2025) who devoted his life to advancing our understanding of the mannose-6-phosphate pathway.