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Complete inhibition of β-tryptase by tetramer dissociation and active site allostery due to a single antibody residue

Crossref DOI link: https://doi.org/10.1038/s41467-026-70491-3

Published Online: 2026-04-09

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Maun, Henry R. https://orcid.org/0000-0002-4909-6061
Azumaya, Caleigh M. https://orcid.org/0000-0002-3484-9921
Walters, Benjamin T. https://orcid.org/0000-0001-5400-0696
Vij, Rajesh

Morando, Ashley https://orcid.org/0009-0000-6659-0777
Loyet, Kelly M. https://orcid.org/0000-0002-3733-099X
Koerber, James T. https://orcid.org/0000-0001-7756-972X
Rohou, Alexis https://orcid.org/0000-0002-3343-9621
Lazarus, Robert A. https://orcid.org/0000-0002-5538-5230
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Text and Data Mining valid from 2026-04-09

Version of Record valid from 2026-04-09
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Article History

Received: 30 May 2025

Accepted: 27 February 2026

First Online: 9 April 2026

Competing interests

: All authors were employees of Genentech, Inc. and shareholders of Roche stock at the time the work was done.