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Authors
Urayama, Syun-ichi https://orcid.org/0000-0001-5318-9212
Fukudome, Akihito https://orcid.org/0000-0001-8924-1035
Mutz, Pascal https://orcid.org/0000-0002-0430-2095
Matsushita, Yosuke https://orcid.org/0000-0002-1325-3125
Takaki, Yoshihiro https://orcid.org/0000-0002-1247-4946
Nishimura, Yosuke https://orcid.org/0000-0002-8028-3228
Medvedeva, Sofia https://orcid.org/0000-0002-7841-0814
Krupovic, Mart https://orcid.org/0000-0001-5486-0098
Koonin, Eugene V. https://orcid.org/0000-0003-3943-8299
Nunoura, Takuro https://orcid.org/0000-0003-2323-0880
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Funding
Funding for this research was provided by:
Ministry of Education, Culture, Sports, Science and Technology (25K22486)
Ministry of Education, Culture, Sports, Science and Technology (23K18146)
Ministry of Education, Culture, Sports, Science and Technology (24K02083)
Ministry of Education, Culture, Sports, Science and Technology (JPMJFR240T)
Ministry of Education, Culture, Sports, Science and Technology (20K20377)
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Article History
Received: 10 September 2025
Accepted: 9 March 2026
First Online: 20 April 2026
Competing interests
: JAMSTEC holds a patent related to a method for fragmentation of double-stranded RNA used in the FLDS protocol (WO2017065194A1; EP3363898B1; CN108513581B; JP6386678B2; US10894981), with S.U. and T.N. listed as inventors. The patent covers technical aspects of the dsRNA fragmentation process and does not impose restrictions on the use of FLDS-derived data or on the publication and reuse of the data reported in this study. All data generated in this work are freely available as described in the “Data Availability” statement. The authors declare no other competing interests.
