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Clinicopathologic and molecular predictors of survival in BRCA-deficient tubo-ovarian high-grade serous carcinoma

Crossref DOI link: https://doi.org/10.1038/s41467-026-71134-3

Published Online: 2026-04-01

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Zwimpfer, Tibor A.

Fereday, Sian https://orcid.org/0000-0002-8559-8579
Pandey, Ahwan https://orcid.org/0000-0003-2238-1054
Ariyaratne, Dinuka https://orcid.org/0000-0001-5704-9030
Jayawardana, Madawa W.

Twomey, Laura

Laumont, Céline M. https://orcid.org/0000-0002-9067-4054
Kennedy, Catherine J.

Bolithon, Adelyn

Meagher, Nicola S. https://orcid.org/0000-0001-9134-2118
Milne, Katy https://orcid.org/0000-0001-5616-1821
Hamilton, Phineas

Alsop, Jennifer

Antoniou, Antonis C.

Au-Yeung, George https://orcid.org/0000-0003-1128-6385
Beckmann, Matthias W.

Berrington de Gonzalez, Amy https://orcid.org/0000-0002-7332-8387
Bisinotto, Christiani

Blome, Freya https://orcid.org/0009-0003-0866-7029
Bodelon, Clara https://orcid.org/0000-0002-6578-2678
Boros, Jessica

Brand, Alison H.

Carney, Michael E.

Cazorla-Jiménez, Alicia

Chiu, Derek S.

Christie, Elizabeth L. https://orcid.org/0000-0002-9959-7024
Chudecka-Głaz, Anita

Coulson, Penny

Cushing-Haugen, Kara L.

Cybulski, Cezary

Darcy, Kathleen M. https://orcid.org/0000-0003-2888-2968
David, Cath

Davidson, Trent

Ekici, Arif B. https://orcid.org/0000-0001-6099-7066
Elishaev, Esther

Emons, Julius

Engler, Tobias https://orcid.org/0000-0002-8063-2053
Farrell, Rhonda

Fischer, Anna

García-Closas, Montserrat

Gentry-Maharaj, Aleksandra

Ghatage, Prafull https://orcid.org/0000-0002-2371-0844
Glasspool, Rosalind

Harter, Philipp

Hartkopf, Andreas D.

Hartmann, Arndt

Heikaus, Sebastian

Hernandez, Brenda Y.

Hettiaratchi, Anusha https://orcid.org/0000-0002-5928-2300
Heublein, Sabine

Huntsman, David G.

Jimenez-Linan, Mercedes

Jones, Michael E. https://orcid.org/0000-0001-7479-3451
Kang, Eunyoung

Kaznowska, Ewa

Kluz, Tomasz

Kommoss, Felix K. F. https://orcid.org/0000-0003-0876-9087
Konecny, Gottfried https://orcid.org/0000-0001-6083-657X
Kruitwagen, Roy F. P. M.

Kwon, Jessica

Lambrechts, Diether https://orcid.org/0000-0002-3429-302X
Lee, Cheng-Han https://orcid.org/0000-0003-2094-1222
Lester, Jenny

Leung, Samuel C. Y.

Leung, Yee https://orcid.org/0000-0003-0349-8652
Linder, Anna https://orcid.org/0000-0002-9444-1346
Lissowska, Jolanta

Loverix, Liselore

Lubiński, Jan

Mateoiu, Constantina

McNeish, Iain A. https://orcid.org/0000-0002-9387-7586
Moubarak, Malak

Nelson, Gregg S. https://orcid.org/0000-0002-8177-1098
Nevins, Nikilyn https://orcid.org/0000-0002-5744-4281
Olawaiye, Alexander B.

Olbrecht, Siel

Orsulic, Sandra https://orcid.org/0000-0001-5119-8721
Osorio, Ana

Quinn, Carmel M.

Mohan, Ganendra Raj

Ray-Coquard, Isabelle https://orcid.org/0000-0003-2472-8306
Rodríguez-Antona, Cristina

Roxburgh, Patricia https://orcid.org/0000-0001-9869-591X
Ruebner, Matthias

Salfinger, Stuart G.

Samra, Spinder

Schoemaker, Minouk J.

Sinn, Hans-Peter https://orcid.org/0000-0003-2836-6699
Sonke, Gabe S. https://orcid.org/0000-0001-8088-9628
Steele, Linda

Stewart, Colin J. R.

Talhouk, Aline

Tan, Adeline

Tarney, Christopher M.

Taylor, Sarah E.

Van de Vijver, Koen K. https://orcid.org/0000-0002-2026-9790
van der Aa, Maaike A.

Van Gorp, Toon https://orcid.org/0000-0002-2564-721X
Van Nieuwenhuysen, Els

Van-Wagensveld, Lilian

Wahner-Hendrickson, Andrea E.

Walter, Christina

Wang, Chen https://orcid.org/0000-0003-2638-3081
Welz, Julia

Wentzensen, Nicolas https://orcid.org/0000-0003-1251-0836
Wilkens, Lynne R.

Winham, Stacey J.

Winterhoff, Boris

Anglesio, Michael S. https://orcid.org/0000-0003-1639-5003
Berchuck, Andrew

Candido dos Reis, Francisco J.

Cohen, Paul A. https://orcid.org/0000-0002-4860-9232
Conrads, Thomas P. https://orcid.org/0000-0003-4742-3281
Crowe, Philip

Doherty, Jennifer A.

Fasching, Peter A. https://orcid.org/0000-0003-4885-8471
Fortner, Renée T.

García, María J.

Gayther, Simon A.

Goodman, Marc T.

Gronwald, Jacek

Harris, Holly R.

Heitz, Florian

Horlings, Hugo M. https://orcid.org/0000-0003-4782-8828
Karlan, Beth Y. https://orcid.org/0000-0002-9451-2933
Kelemen, Linda E.

Larry Maxwell, G.

Menon, Usha https://orcid.org/0000-0003-3708-1732
Modugno, Francesmary

Neuhausen, Susan L. https://orcid.org/0000-0001-5053-0390
Schildkraut, Joellen M.

Staebler, Annette

Sundfeldt, Karin

Swerdlow, Anthony J.

Vergote, Ignace

Wu, Anna H.

Brenton, James D. https://orcid.org/0000-0002-5738-6683
Pharoah, Paul D. P. https://orcid.org/0000-0001-8494-732X
Pearce, Celeste Leigh

Pike, Malcolm C.

Goode, Ellen L. https://orcid.org/0000-0002-9094-8326
Ramus, Susan J. https://orcid.org/0000-0003-0005-7798
Köbel, Martin https://orcid.org/0000-0002-6615-2037
Nelson, Brad H. https://orcid.org/0000-0002-4445-5539
DeFazio, Anna https://orcid.org/0000-0003-0057-4744
Friedlander, Michael L. https://orcid.org/0000-0003-3090-795X
Bowtell, David D. L.

Garsed, Dale W. https://orcid.org/0000-0003-1223-0121
Funding

Funding for this research was provided by:

Department of Health | National Health and Medical Research Council (GNT1186505, GNT2029088, 2009840, 2033042)

Gottfried und Julia Bangerter-Rhyner-Stiftung (0297)

Medizinische Abteilung der Margarete und Walter Lichtenstein-Stiftung

Victorian Cancer Agency (MCRF22018)

Ovarian Cancer Research Foundation (2025/OCRF0071)

Breast Cancer Now
License Information

Text and Data Mining valid from 2026-04-01

Accepted Manuscript valid from 2026-04-01
More Information

Article History

Received: 22 September 2025

Accepted: 13 March 2026

First Online: 1 April 2026

Competing interests

: T.A.Z. reports personal consulting fees from AbbVie that are outside the submitted work. D.D.L.B. reports research support grants from AstraZeneca, Roche-Genentech and BeiGene paid to institution outside the submitted work; also, personal consulting fees from Exo Therapeutics that are outside the submitted work. G.A.-Y. reports research support grants from AstraZeneca and Roche-Genentech paid to institution outside the submitted work; also, personal consulting fees from Incyclix Bio that are outside the submitted work. A.DeF. reports research support from AstraZeneca and Illumina. N.N. reports research support from Illumina. P.A.C. reports speakers’ honoraria from AstraZeneca, Merck Sharpe and Dohme, and GlaxoSmithKline, and personal consulting fees from Astra Zeneca outside the remit of the submitted work. U.M. and A.G.M. report personal consulting fees from Mercy BioAnalytics Ltd and research support grants from Intelligent Lab on Fiber, RNA Guardian, and MercyBio Analytics that are all outside the remit of the submitted work. E.L.C. reports research support from AstraZeneca paid to institution outside the submitted work and speakers’ honoraria from AstraZeneca and GSK. S.E.T reports consulting fees from AstraZeneca and IntegraConnect outside the submitted work. P.H. reports honoraria and consulting fees from Amgen, Astra Zeneca, GSK, Roche, Immunogen, Sotio, Stryker, ZaiLab, MSD, Clovis, Miltenyi, Eisai, Mersana, Exscientia, Daiichi Sankyo, Karyopharm, Abbvie, Novartis, Corcept, BionTech, Zymeworks and Research funding (Institutional) from Astra Zeneca, Roche, GSK, Genmab, Immunogen, Seagen, Clovis, Novartis, Immatics, Abbvie, MSD. I.V. has participated in consulting advisory boards for Akesobio, Bristol Myers Squibb, Eisai, F. Hoffmann-La Roche, Genmab, GSK, ITM, Karyopharm, MSD, Novocure, Oncoinvent, Sanofi, Regeneron, and Seagen, and has participated in consulting data monitoring committees for Abbvie, Agenus, AstraZeneca, Corcept, Daiichi, F. Hoffmann-La Roche, Immunogen, Kronos Bio, Mersana, Novartis, OncXerna, Verastem Oncology, and Zentalis. The remaining authors declare no competing interests.

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