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Multi-trait polygenic risk scores improve genomic prediction of atrial fibrillation across diverse ancestries

Crossref DOI link: https://doi.org/10.1038/s41467-026-72708-x

Published Online: 2026-05-05

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Haydarlou, Poeya https://orcid.org/0009-0000-3938-3377
Kramarenko, Daria R.

Enzan, Nobuyuki https://orcid.org/0000-0002-3899-4405
Klevjer, Marie https://orcid.org/0000-0001-8372-276X
Vad, Oliver B.

Corver, Marre E.

Zimmerman, Dominic S.

,

Matsuda, Koichi

Morisaki, Takayuki

Okada, Yukinori

Kamatani, Yoichiro

Muto, Kaori

Nagai, Akiko

Sagiya, Yoji

Kumasaka, Natsuhiko

Furukawa, Yoichi

Yamanashi, Yuji

Murakami, Yoshinori

Nakamura, Yusuke

Obara, Wataru

Yamaji, Ken

Takahashi, Kazuhisa

Asai, Satoshi

Takahashi, Yasuo

Higashiue, Shinichi

Kobayashi, Shuzo

Yamaguchi, Hiroki

Nagata, Yasunobu

Wakita, Satoshi

Nito, Chikako

Iwasaki, Yu-ki

Murayama, Shigeo

Yoshimori, Kozo

Miki, Yoshio

Obata, Daisuke

Higashiyama, Masahiko

Masumoto, Akihide

Koga, Yoshinobu

Koretsune, Yukihiro

Matsuda, Koichi https://orcid.org/0000-0001-7292-2686
Diederichsen, Søren Z. https://orcid.org/0000-0002-9687-0857
Bye, Anja

Svendsen, Jesper H. https://orcid.org/0000-0001-8466-8515
Ito, Kaoru https://orcid.org/0000-0003-1843-773X
Ellinor, Patrick T.

Bezzina, Connie R. https://orcid.org/0000-0002-0633-3514
Jurgens, Sean J. https://orcid.org/0000-0002-1605-9782
License Information

Text and Data Mining valid from 2026-05-05

Accepted Manuscript valid from 2026-05-05
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Article History

Received: 25 September 2025

Accepted: 23 April 2026

First Online: 5 May 2026

Competing interests

: P.T.E. has received sponsored research support from Bayer AG, Bristol Myers Squibb, Pfizer, and Novo Nordisk, and he has consulted for Bayer AG. S.Z.D. reports consultancy fees from Bristol-Myers Squibb/Pfizer, Cortrium, Medtronic, Novo Nordisk, and Acesion Pharma, speaker fees from Bristol-Myers Squibb/Pfizer, Bayer, and AstraZeneca, to be a part-time employee of Vital Beats, and to have received travel grants from Abbott and Boston Scientific. J.H.S. reports to be member of advisory boards in Medtronic and Vital Beats, and to have received research grants from Medtronic. All declared activities are not related to the current work. The remaining authors declare no competing interests.

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