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Engineered dCas12f1-SAM enables robust transcriptional activation and gain-of-function screening in primary human cells

Crossref DOI link: https://doi.org/10.1038/s41467-026-72833-7

Published Online: 2026-05-06

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Cao, Jiaxuan

Liu, Zhirui https://orcid.org/0009-0000-8245-3123
Chen, Xinwen

Lan, Zilin

Liu, Li

Zhai, Yixin

Wang, Wentian

Xue, Chaoyou https://orcid.org/0000-0002-5323-6178
Cheng, Hui https://orcid.org/0000-0002-1988-6572
Yao, Yao https://orcid.org/0000-0002-4224-1369
Cheng, Tao https://orcid.org/0000-0003-4395-1095
Rao, Shuquan https://orcid.org/0000-0003-4281-2392
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Text and Data Mining valid from 2026-05-06

Accepted Manuscript valid from 2026-05-06
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Article History

Received: 9 April 2024

Accepted: 20 April 2026

First Online: 6 May 2026

Competing interests

: The authors declare no competing interests.