Han, Xia https://orcid.org/0000-0001-8116-7694
Rosenberg, Gregory M. https://orcid.org/0000-0002-1297-1715
Kisling, Vivianne M.
Zhang, Tao
Lee, Chia-Yi https://orcid.org/0000-0003-4529-7103
Ravi, Ashvin
Melnik, Mikhail
Bilousova, Tina
Spina, Salvatore https://orcid.org/0000-0003-3570-9143
Nana, Alissa L. https://orcid.org/0000-0003-3474-8044
Grinberg, Lea T. https://orcid.org/0000-0002-6809-0618
Seeley, William W. https://orcid.org/0000-0003-1410-2027
Gylys, Karen H.
Huckins, Laura M. https://orcid.org/0000-0002-5369-6502
Raj, Towfique https://orcid.org/0000-0002-9355-5704
Brennand, Kristen J. https://orcid.org/0000-0003-0993-5956
Rexach, Jessica E. https://orcid.org/0000-0002-4462-7249
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Institute on Aging (R01 AG075802, R01 RF1NS128800)
U.S. Department of Health & Human Services | NIH | National Institute on Aging (R21AG082014)
U.S. Department of Health & Human Services | NIH | National Institute on Aging (R01 AG075802)
U.S. Department of Health & Human Services | NIH | National Institute on Aging (R21AG082014)
U.S. Department of Health & Human Services | NIH | National Institute on Aging (RF1AG065926)
U.S. Department of Health & Human Services | NIH | National Institute on Aging (R01AG068030, RF1AG065926, R01AG050986)
Rainwater Charitable Foundation, Ono Pharmaceuticals
U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (R01ES033630)
Article History
Received: 6 June 2025
Accepted: 23 April 2026
First Online: 14 May 2026
Competing interests
: Dr. Seeley serves as a paid consultant for Lyterian Therapeutics and Trace Neuroscience. The other authors declare they have no competing interests.