Yuan, Baolei https://orcid.org/0000-0003-4159-3319
Tian, Yeteng https://orcid.org/0000-0003-0220-1538
Lin, Wei-Bin https://orcid.org/0000-0001-6839-5561
Bi, Chongwei https://orcid.org/0000-0003-2108-1551
Zhang, Yingzi
Jin, Yiqing https://orcid.org/0000-0001-5454-6517
Maatouk, Batoul
Khashab, Niveen M. https://orcid.org/0000-0003-2728-0666
Funding for this research was provided by:
King Abdullah University of Science and Technology (BAS/1/1080-01-01)
KAUST Center of Excellence for Smart Health (KCSH), under award number 5932
Article History
Received: 25 June 2025
Accepted: 22 May 2026
First Online: 2 June 2026
Competing interests
: King Abdullah University of Science and Technology (KAUST) has filed a patent application related to the methods described in this study, with B.Y. and M.L. listed as inventors (U.S. Provisional Patent Application No. 63/639,573; pending PCT conversion). The application covers methods for improving CRISPR–Cas-mediated precise genome editing using chemically modified single-stranded oligodeoxynucleotide (ssODN) donors, including cyanine-modified ssODNs. The authors declare no other competing interests.