Walter, Mateusz https://orcid.org/0009-0001-7023-4545
Finocchio, Giada https://orcid.org/0000-0001-6905-9308
Oberli, Seraina https://orcid.org/0000-0002-3568-7637
Hammerschmid, Iana C. https://orcid.org/0009-0003-6670-6196
Lampe, George D. https://orcid.org/0000-0002-2873-2372
Karan, Julia https://orcid.org/0009-0005-8284-7225
Swartjes, Thomas https://orcid.org/0000-0001-7528-5483
Sternberg, Samuel H. https://orcid.org/0000-0001-8240-9114
Jinek, Martin https://orcid.org/0000-0002-7601-210X
Querques, Irma https://orcid.org/0000-0003-1113-2773
Funding for this research was provided by:
EC | Horizon 2020 Framework Programme (101115765 BROADCAST)
EC | Horizon 2020 Framework Programme (820152 CRISPR2.0)
Vallee Foundation (Vallee Scholar Award)
Österreichischen Akademie der Wissenschaften (DOC fellowship)
Österreichischen Akademie der Wissenschaften (DOC fellowship)
The Branco Weiss Fellowship – Society in Science, administered by ETH Zürich
U.S. Department of Health & Human Services | National Institutes of Health (RM1HG009490)
U.S. Department of Health & Human Services | National Institutes of Health (R01EB027793)
U.S. Department of Health & Human Services | National Institutes of Health (R01EB031935)
U.S. Department of Health & Human Services | National Institutes of Health (DP2HG011650)
Howard Hughes Medical Institute
Pew Biomedical Scholarship Irma T. Hirschl Career Scientist Award Columbia University Irving Medical Center Dean’s Office Vagelos Precision Medicine Fund
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (320030-228089)
Swiss National Center for Competence in Research (NCCR) RNA & Disease
Article History
Received: 18 December 2025
Accepted: 6 August 2026
First Online: 24 August 2026
Ethics
Competing interests: G.D.L. and S.H.S. are inventors on patent applications related to CAST systems and uses thereof. All remaining authors declare no competing interests.