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Authors
Vedi, Aditi https://orcid.org/0000-0001-6761-6510
Trotman, Jamie https://orcid.org/0000-0002-6246-4121
Dias, Joao M. L. https://orcid.org/0000-0002-8451-3537
Mijuskovic, Martina
Choi, Sera
Kingham, Laura
Moore, Rachel A.
Leiter, Sarah M. https://orcid.org/0000-0001-8321-3260
Guermech, Rowena
Semerene, Amanda
Grisby, Aviva
Wool, Sophie
Joslin, Victoria
Mahendrayogam, Arunthethy
Abrams, Jonathan https://orcid.org/0000-0002-4044-6969
Gattens, Michael
Blanco, Esther
Dickens, Emmy L.
Burns, Charlotte
Murray, Matthew J. https://orcid.org/0000-0002-4480-1147
Tadross, John A. https://orcid.org/0000-0002-8424-1252
Trayers, Claire
Hook, Catherine E. https://orcid.org/0000-0002-0450-7656
Becq, Jennifer
Newington, Taksina
Armogida, Ivana
Kingsbury, Zoya
Grobecker, Pascal https://orcid.org/0009-0001-8339-4775
Vitoriano, Ines
Bekritsky, Mitchell A.
Weir, Jacqueline
Fraser, Louise J. https://orcid.org/0000-0001-9709-6827
Ross, Mark
Bentley, David
Cullen, Matthew
Behjati, Sam https://orcid.org/0000-0002-6600-7665
Bartram, Jack
Humphray, Sean J.
Tarpey, Patrick https://orcid.org/0000-0002-2042-4543
Rowitch, David https://orcid.org/0000-0002-0079-0060
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Funding
Funding for this research was provided by:
Rosetrees Trust (CF-2023-I-2\104)
Rosetrees Trust (CF-2023-I-2\104)
Isaac Newton Trust
Wellcome Trust (312471/Z/24/Z)
CUH | Addenbrooke's Charitable Trust, Cambridge University Hospitals
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Article History
Received: 12 February 2026
Accepted: 8 September 2026
First Online: 6 October 2026
Ethics
Competing interests: M.M., S.C., P.G., Z.K., J.B., T.N., I.A., I.V., M.B., L.J.F., J.W., M.R., D.B. and S.H. are or were employees of Illumina during the study. All other authors declare no competing interests. Study protocol. The analysis protocol is publicly available at protocols.io: .
