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Funding for this research was provided by:
Bill and Melinda Gates Foundation (008053)
Bill and Melinda Gates Foundation (008053)
Bill and Melinda Gates Foundation (008053)
Bill and Melinda Gates Foundation (008053)
Bill and Melinda Gates Foundation (008053)
Bill and Melinda Gates Foundation (008053)
Bill and Melinda Gates Foundation (008053)
Bill and Melinda Gates Foundation (008053)
Bill and Melinda Gates Foundation (008053)
Bill and Melinda Gates Foundation (008053)
Bill and Melinda Gates Foundation (008053)
Bill and Melinda Gates Foundation (008053)
Bill and Melinda Gates Foundation (008053)
Bill and Melinda Gates Foundation (008053)
Bill and Melinda Gates Foundation (58147)
Bill and Melinda Gates Foundation (008053)
Bill and Melinda Gates Foundation (008053)
Article History
Received: 13 June 2025
Accepted: 21 October 2025
First Online: 17 December 2025
Competing interests
: W.Z., U.S., W.G., H.E.N. and L.B. are inventors on patent applications that were filed for AKT2 var under International Patent Application No. PCT/EP2025/064398. The other authors declare no competing interests.