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Frailty-related plasma metabolomic signatures predict long-term mortality risk and implicate systemic aging pathways: evidence from a prospective cohort study

Crossref DOI link: https://doi.org/10.1038/s41514-025-00327-9

Published Online: 2026-01-13

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Zhang, Xiru

Feng, Xin

Liu, Wenchao

Liu, Ruiyan

Huang, Qingmei

Zhang, Peidong

Li, Zhihao

Li, Xifeng

Mao, Chen https://orcid.org/0000-0002-6537-6215
Duan, Chuanzhi https://orcid.org/0000-0002-2025-8637
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (82304211)

National Natural Science Foundation of China (82201427)

National Natural Science Foundation of China (82425052)

National Natural Science Foundation of China (82271298)

National Heath Commission Capacity Building and Continuing Education Center (GWJJ2022100102)
License Information

Text and Data Mining valid from 2026-01-13

Accepted Manuscript valid from 2026-01-13
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Article History

Received: 19 August 2025

Accepted: 29 December 2025

First Online: 13 January 2026

Competing interests

: The authors declare no competing interests.

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