Upthegrove, Rachel
Couch, Amalie C. M.
de Marvao, Antonio
Perry, Benjamin I.
Corsi-Zuelli, Fabiana
Rogers, Jack
Handunnetthi, Lahiru
Barnes, Nicholas M.
Koutsouleris, Nikolaos
Lalousis, Paris A.
Pillinger, Toby
Freyberg, Zachary
Funding for this research was provided by:
NIHR (NIHR203316)
Article History
Received: 13 January 2026
Accepted: 15 May 2026
First Online: 29 May 2026
Ethics
Competing interests: R.U. reports consultancy for Bristol Meyers Squibb and speaker fee for educational events from Otuska and Viatris outside of the current work. T.P. has received speaker or consultancy fees from Boehringer Ingelheim, Bristol Myers Squibb, CNX Therapeutics, Janssen, Lecturing Minds Stockholm AB, Lundbeck, Otsuka, Recordati, ROVI Biotech, Schwabe Pharma, Sunovion, and Teva Pharmaceuticals; he receives book royalties from Wiley Blackwell; and he co-directs a company that designs digital resources to support treatment of mental illness. B.I.P. is founder of the PsyMetRiC Operating Division in partnership with University of Birmingham Enterprise, but does not receive any direct personal financial benefit. B.I.P. is Topic Advisor for Severe and Enduring Mental Illness for the National Institute for Health and Care Excellence (NICE). B.I.P. is a member of the Digital Mental Health A.I. Airlock Governance Board for the Medicines and Healthcare products Regulatory Agency (MHRA). P.A.L. has received honoraria for talks presented at educational meetings organized by Boehringer Ingelheim outside of the submitted work reports being a Director and shareholder of Celentyx Ltd although these associations are outside the current work.