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Article History

Received: 17 April 2020

Accepted: 16 February 2021

First Online: 20 May 2021

Competing interests

: L.T.V. declares no competing interest; P.S. consulting for the following: Pfizer, AstraZeneca, Novartis, Roche, Merck, Boehringer Ingelheim, Bayer, Eisai, Celgene, Puma and funding from the following: Roche, Genentech, Oncogenex, Novartis; A.F.-T. an employee with Seattle Genetics in November 2018. Received research support paid to the institution from Celldex; K.B. Lilli company, and Tempus labs; M.L.T. advisory role: Celldex (12/2017), Immunomedics, Daiichi Sankyo, Genentech, Merck, Celgene, Lilly, AbbVie, Aduro, Pfizer. DSMC: Immunomedics, G1 Therapeutics. Research funding to the institution: Merck, Genentech, AbbVie, Pfizer, PharmaMar, Tesaro, OncoSec, Biothera, Calithera, Vertex, EMD Serono, Bayer; M.M. no competing interest; V.M. declares no competing interest; J.C. Advisor: Roche, Celgene, Cellestia, AstraZeneca, Biothera Pharmaceutical, Merus, Seattle Genetics, Daiichi Sankyo, Erytech, Athenex, Polyphor, Lilly, Servier, Merck Sharp&Dohme, GSK, Leuko, Bioasis, Clovis Oncology, Boehringer Ingelheim. Honoraria: Roche, Novartis, Celgene, Eisai, Pfizer, Samsung Bioepis, Lilly, Merck Sharp&Dohme, Daiichi Sankyo. Research funding to the institution: Roche, Ariad pharmaceuticals, AstraZeneca, Baxalta GMBH/Servier Affaires, Bayer healthcare, Eisai, F. Hoffman-La Roche, Guardanth health, Merck Sharp&Dohme, Pfizer, Piqur Therapeutics, Puma C, Queen Mary University of London. Stock, patents, and intellectual property: MedSIR. Travel, accommodation, expenses: Roche, Novartis, Eisai, Pfizer, Daiichi Sankyo.; A.J.M. declares no competing interest. C.M. research support: Puma and Pfizer (clinical trial funding and preclinical studies). Consultant: Puma, Eli Lilly, Pfizer, Novartis (DSMB), Myriad, Seattle Genetics, Agendia, AstraZeneca, Phillips Electronics; R.N. Advisory board: Aduro, AstraZeneca, Ethnics, Celgene, Clovis, Daiichi Sankyo, Inc, Genentech, Immunomedics, MacroGenics, Merck, Novartis, Pfizer, Puma, Seattle Genetics, Syndax. DSMB:G1 Therapeutics. Research Funding: AstraZeneca, Celgene, Corcept Therapeutics, Genentech/Roche, Immunomedics, Merck, OBI Pharm, Inc., Odonate Therapeutics, Pfizer, Seattle Genetics; G.S.W. Received research support paid to the institution from Celldex; D.Y. Research funding: AbbVie, BioMarin, Clovis, Dana Farber Cancer Institute, Eisai, Lilly, G1 Therapeutics, Genentech, Incyte, Innocrin Pharmaceuticals, MacroGenics, MedImmune, Medication, Merck, Merrimack Pharmaceuticals, Nektar, Novartis, NSABP, Odonate Therapeutics, Pfizer, Tesero and US Oncology. Personal financial interest: AbbVie, BMS, Genentech, Immunomedics, Novartis. Y.H., T.H., R.G.B., A-B.H., and C.T. all were employees of Celldex during the conduct of the study and owned company stock.